The loss-of-function of DNA methyltransferase 1 by siRNA impairs the growth of non-small cell lung cancer with alleviated side effects via reactivation of RASSF1A and APC in vitro and vivo

Hypermethylation of tumor suppressor genes (TSGs) promoters by DNA methyltransferase (DNMT) can be observed in almost all cancers which represent a hallmark of carcinogenesis, including lung cancer. DNMT inhibitors (e.g.5-Aza-CR/CdR) reactivate TSGs to exert anti-cancer activity and have been applie...

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Detalles Bibliográficos
Autores principales: Lai, Qi, Xu, Yin-Hui, Chen, Qiang, Tang, Liang, Li, An-Gui, Zhang, Li-Fei, Zhang, Chun-Fang, Song, Jian-Fei, Du, Zhen-Zong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601733/
https://www.ncbi.nlm.nih.gov/pubmed/28938637
http://dx.doi.org/10.18632/oncotarget.19573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601733/
https://www.ncbi.nlm.nih.gov/pubmed/28938637
http://dx.doi.org/10.18632/oncotarget.19573

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