Positive transcription elongation factor b (P-TEFb) is a therapeutic target in human multiple myeloma

The role of the positive RNA Pol II regulator, P-TEFb (positive transcription elongation factor b), in maintenance of the anti-apoptotic protein Mcl-1 and bortezomib (btz) resistance was investigated in human multiple myeloma (MM) cells. Mcl-1 was up-regulated in all MM lines tested, including borte...

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Detalles Bibliográficos
Autores principales: Zhang, Yu, Zhou, Liang, Leng, Yun, Dai, Yun, Orlowski, Robert Z., Grant, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601747/
https://www.ncbi.nlm.nih.gov/pubmed/28938651
http://dx.doi.org/10.18632/oncotarget.19761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601747/
https://www.ncbi.nlm.nih.gov/pubmed/28938651
http://dx.doi.org/10.18632/oncotarget.19761

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