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Meta-analysis of the association between the inflammatory potential of diet and colorectal cancer risk

OBJECTIVES: The inflammatory potential of diet has been inconsistently linked to colorectal cancer (CRC) risk. This meta-analysis aimed to evaluate the association of the inflammatory potential of diet, as estimated by the dietary inflammatory index (DII) score, with CRC risk. MATERIALS AND METHODS:...

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Autores principales: Fan, Yu, Jin, Xin, Man, Changfeng, Gao, Zhenjun, Wang, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601758/
https://www.ncbi.nlm.nih.gov/pubmed/28938662
http://dx.doi.org/10.18632/oncotarget.19233
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author Fan, Yu
Jin, Xin
Man, Changfeng
Gao, Zhenjun
Wang, Xiaoyan
author_facet Fan, Yu
Jin, Xin
Man, Changfeng
Gao, Zhenjun
Wang, Xiaoyan
author_sort Fan, Yu
collection PubMed
description OBJECTIVES: The inflammatory potential of diet has been inconsistently linked to colorectal cancer (CRC) risk. This meta-analysis aimed to evaluate the association of the inflammatory potential of diet, as estimated by the dietary inflammatory index (DII) score, with CRC risk. MATERIALS AND METHODS: The PubMed and Embase databases were searched for relevant studies from inception to February 2017. All cohort and case–control studies investigating the association of the DII score with CRC risk were selected. RESULTS: Four prospective cohorts and four case–control studies, which enrolled a total of 880,380 participants, were included. The pooled adjusted risk ratio (RR) of CRC for the highest DII score versus the lowest category was 1.43 (95% confidence interval [CI]: 1.26–1.62). When stratified by study design, the RRs for the case–control and cohort studies were 1.27 (95% CI: 1.16–1.38) and 1.81 (95% CI: 1.48–2.22), respectively. Subgroup analysis showed that individuals with the highest category of DII score were independently associated with CRC risk in men (RR=1.51; 95% CI: 1.29–1.76), women (RR=1.25; 95% CI: 1.10–1.41), colon cancer (RR=1.39; 95% CI: 1.19–1.62), and rectal cancer (RR=1.32; 95% CI: 1.01–1.74). However, the pooled RR was 1.07 (95% CI: 0.87–1.31) for rectal cancer among the prospective cohort studies. CONCLUSIONS: As estimated by a high DII score, pro-inflammatory diet is independently associated with increased CRC risk. This finding confirms that low inflammatory potential diet may reduce CRC risk. However, the gender- and cancer site-specific associations of the DII score with CRC risk need to be further investigated.
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spelling pubmed-56017582017-09-21 Meta-analysis of the association between the inflammatory potential of diet and colorectal cancer risk Fan, Yu Jin, Xin Man, Changfeng Gao, Zhenjun Wang, Xiaoyan Oncotarget Meta-Analysis OBJECTIVES: The inflammatory potential of diet has been inconsistently linked to colorectal cancer (CRC) risk. This meta-analysis aimed to evaluate the association of the inflammatory potential of diet, as estimated by the dietary inflammatory index (DII) score, with CRC risk. MATERIALS AND METHODS: The PubMed and Embase databases were searched for relevant studies from inception to February 2017. All cohort and case–control studies investigating the association of the DII score with CRC risk were selected. RESULTS: Four prospective cohorts and four case–control studies, which enrolled a total of 880,380 participants, were included. The pooled adjusted risk ratio (RR) of CRC for the highest DII score versus the lowest category was 1.43 (95% confidence interval [CI]: 1.26–1.62). When stratified by study design, the RRs for the case–control and cohort studies were 1.27 (95% CI: 1.16–1.38) and 1.81 (95% CI: 1.48–2.22), respectively. Subgroup analysis showed that individuals with the highest category of DII score were independently associated with CRC risk in men (RR=1.51; 95% CI: 1.29–1.76), women (RR=1.25; 95% CI: 1.10–1.41), colon cancer (RR=1.39; 95% CI: 1.19–1.62), and rectal cancer (RR=1.32; 95% CI: 1.01–1.74). However, the pooled RR was 1.07 (95% CI: 0.87–1.31) for rectal cancer among the prospective cohort studies. CONCLUSIONS: As estimated by a high DII score, pro-inflammatory diet is independently associated with increased CRC risk. This finding confirms that low inflammatory potential diet may reduce CRC risk. However, the gender- and cancer site-specific associations of the DII score with CRC risk need to be further investigated. Impact Journals LLC 2017-07-14 /pmc/articles/PMC5601758/ /pubmed/28938662 http://dx.doi.org/10.18632/oncotarget.19233 Text en Copyright: © 2017 Fan et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Meta-Analysis
Fan, Yu
Jin, Xin
Man, Changfeng
Gao, Zhenjun
Wang, Xiaoyan
Meta-analysis of the association between the inflammatory potential of diet and colorectal cancer risk
title Meta-analysis of the association between the inflammatory potential of diet and colorectal cancer risk
title_full Meta-analysis of the association between the inflammatory potential of diet and colorectal cancer risk
title_fullStr Meta-analysis of the association between the inflammatory potential of diet and colorectal cancer risk
title_full_unstemmed Meta-analysis of the association between the inflammatory potential of diet and colorectal cancer risk
title_short Meta-analysis of the association between the inflammatory potential of diet and colorectal cancer risk
title_sort meta-analysis of the association between the inflammatory potential of diet and colorectal cancer risk
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601758/
https://www.ncbi.nlm.nih.gov/pubmed/28938662
http://dx.doi.org/10.18632/oncotarget.19233
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