Cargando…

Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease

The association of the CYP2J2 G-50T polymorphism with coronary artery disease has been explored, but the results remain controversial. Thus, a meta-analysis was conducted to provide a comprehensive estimate of this association. We selected ten articles encompassing 12 independent case-control studie...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Jian, Wang, Dong-Fei, Fu, Guo-Dong, Ding, Jie, Chen, Lei-Yang, Lv, Jia-Lan, Fang, Juan, Yin, Xiang, Guo, Xiao-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601761/
https://www.ncbi.nlm.nih.gov/pubmed/28938665
http://dx.doi.org/10.18632/oncotarget.19518
_version_ 1783264450887811072
author Chen, Jian
Wang, Dong-Fei
Fu, Guo-Dong
Ding, Jie
Chen, Lei-Yang
Lv, Jia-Lan
Fang, Juan
Yin, Xiang
Guo, Xiao-Gang
author_facet Chen, Jian
Wang, Dong-Fei
Fu, Guo-Dong
Ding, Jie
Chen, Lei-Yang
Lv, Jia-Lan
Fang, Juan
Yin, Xiang
Guo, Xiao-Gang
author_sort Chen, Jian
collection PubMed
description The association of the CYP2J2 G-50T polymorphism with coronary artery disease has been explored, but the results remain controversial. Thus, a meta-analysis was conducted to provide a comprehensive estimate of this association. We selected ten articles encompassing 12 independent case-control studies with 7063 cases and 10,453 controls for this meta-analysis. Overall, we found significant associations between the CYP2J2 G-50T polymorphism and coronary artery disease risk in three genetic models (allele model: odds ratio (OR) = 1.19, 95% confidence interval (CI) = 1.05–1.34; homozygote model: OR = 2.25, 95% CI = 1.27–4.01; recessive model: OR = 2.17, 95% CI = 1.22–3.86). In these three genetic models, a significant association was observed in Caucasians but not in Asians when the data were stratified by ethnicity. However, no significant associations were found between the CYP2J2 polymorphism G-50T and coronary artery disease risk in heterozygote model and dominant model. In conclusion, our meta-analysis suggested that the CYP2J2 G-50T polymorphism was associated with coronary artery disease risk in the allele, homozygote and recessive models in Caucasians.
format Online
Article
Text
id pubmed-5601761
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-56017612017-09-21 Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease Chen, Jian Wang, Dong-Fei Fu, Guo-Dong Ding, Jie Chen, Lei-Yang Lv, Jia-Lan Fang, Juan Yin, Xiang Guo, Xiao-Gang Oncotarget Meta-Analysis The association of the CYP2J2 G-50T polymorphism with coronary artery disease has been explored, but the results remain controversial. Thus, a meta-analysis was conducted to provide a comprehensive estimate of this association. We selected ten articles encompassing 12 independent case-control studies with 7063 cases and 10,453 controls for this meta-analysis. Overall, we found significant associations between the CYP2J2 G-50T polymorphism and coronary artery disease risk in three genetic models (allele model: odds ratio (OR) = 1.19, 95% confidence interval (CI) = 1.05–1.34; homozygote model: OR = 2.25, 95% CI = 1.27–4.01; recessive model: OR = 2.17, 95% CI = 1.22–3.86). In these three genetic models, a significant association was observed in Caucasians but not in Asians when the data were stratified by ethnicity. However, no significant associations were found between the CYP2J2 polymorphism G-50T and coronary artery disease risk in heterozygote model and dominant model. In conclusion, our meta-analysis suggested that the CYP2J2 G-50T polymorphism was associated with coronary artery disease risk in the allele, homozygote and recessive models in Caucasians. Impact Journals LLC 2017-07-24 /pmc/articles/PMC5601761/ /pubmed/28938665 http://dx.doi.org/10.18632/oncotarget.19518 Text en Copyright: © 2017 Chen et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Meta-Analysis
Chen, Jian
Wang, Dong-Fei
Fu, Guo-Dong
Ding, Jie
Chen, Lei-Yang
Lv, Jia-Lan
Fang, Juan
Yin, Xiang
Guo, Xiao-Gang
Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease
title Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease
title_full Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease
title_fullStr Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease
title_full_unstemmed Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease
title_short Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease
title_sort meta-analysis of the association of the cyp2j2 g-50t polymorphism with coronary artery disease
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601761/
https://www.ncbi.nlm.nih.gov/pubmed/28938665
http://dx.doi.org/10.18632/oncotarget.19518
work_keys_str_mv AT chenjian metaanalysisoftheassociationofthecyp2j2g50tpolymorphismwithcoronaryarterydisease
AT wangdongfei metaanalysisoftheassociationofthecyp2j2g50tpolymorphismwithcoronaryarterydisease
AT fuguodong metaanalysisoftheassociationofthecyp2j2g50tpolymorphismwithcoronaryarterydisease
AT dingjie metaanalysisoftheassociationofthecyp2j2g50tpolymorphismwithcoronaryarterydisease
AT chenleiyang metaanalysisoftheassociationofthecyp2j2g50tpolymorphismwithcoronaryarterydisease
AT lvjialan metaanalysisoftheassociationofthecyp2j2g50tpolymorphismwithcoronaryarterydisease
AT fangjuan metaanalysisoftheassociationofthecyp2j2g50tpolymorphismwithcoronaryarterydisease
AT yinxiang metaanalysisoftheassociationofthecyp2j2g50tpolymorphismwithcoronaryarterydisease
AT guoxiaogang metaanalysisoftheassociationofthecyp2j2g50tpolymorphismwithcoronaryarterydisease