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Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease
The association of the CYP2J2 G-50T polymorphism with coronary artery disease has been explored, but the results remain controversial. Thus, a meta-analysis was conducted to provide a comprehensive estimate of this association. We selected ten articles encompassing 12 independent case-control studie...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601761/ https://www.ncbi.nlm.nih.gov/pubmed/28938665 http://dx.doi.org/10.18632/oncotarget.19518 |
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author | Chen, Jian Wang, Dong-Fei Fu, Guo-Dong Ding, Jie Chen, Lei-Yang Lv, Jia-Lan Fang, Juan Yin, Xiang Guo, Xiao-Gang |
author_facet | Chen, Jian Wang, Dong-Fei Fu, Guo-Dong Ding, Jie Chen, Lei-Yang Lv, Jia-Lan Fang, Juan Yin, Xiang Guo, Xiao-Gang |
author_sort | Chen, Jian |
collection | PubMed |
description | The association of the CYP2J2 G-50T polymorphism with coronary artery disease has been explored, but the results remain controversial. Thus, a meta-analysis was conducted to provide a comprehensive estimate of this association. We selected ten articles encompassing 12 independent case-control studies with 7063 cases and 10,453 controls for this meta-analysis. Overall, we found significant associations between the CYP2J2 G-50T polymorphism and coronary artery disease risk in three genetic models (allele model: odds ratio (OR) = 1.19, 95% confidence interval (CI) = 1.05–1.34; homozygote model: OR = 2.25, 95% CI = 1.27–4.01; recessive model: OR = 2.17, 95% CI = 1.22–3.86). In these three genetic models, a significant association was observed in Caucasians but not in Asians when the data were stratified by ethnicity. However, no significant associations were found between the CYP2J2 polymorphism G-50T and coronary artery disease risk in heterozygote model and dominant model. In conclusion, our meta-analysis suggested that the CYP2J2 G-50T polymorphism was associated with coronary artery disease risk in the allele, homozygote and recessive models in Caucasians. |
format | Online Article Text |
id | pubmed-5601761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56017612017-09-21 Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease Chen, Jian Wang, Dong-Fei Fu, Guo-Dong Ding, Jie Chen, Lei-Yang Lv, Jia-Lan Fang, Juan Yin, Xiang Guo, Xiao-Gang Oncotarget Meta-Analysis The association of the CYP2J2 G-50T polymorphism with coronary artery disease has been explored, but the results remain controversial. Thus, a meta-analysis was conducted to provide a comprehensive estimate of this association. We selected ten articles encompassing 12 independent case-control studies with 7063 cases and 10,453 controls for this meta-analysis. Overall, we found significant associations between the CYP2J2 G-50T polymorphism and coronary artery disease risk in three genetic models (allele model: odds ratio (OR) = 1.19, 95% confidence interval (CI) = 1.05–1.34; homozygote model: OR = 2.25, 95% CI = 1.27–4.01; recessive model: OR = 2.17, 95% CI = 1.22–3.86). In these three genetic models, a significant association was observed in Caucasians but not in Asians when the data were stratified by ethnicity. However, no significant associations were found between the CYP2J2 polymorphism G-50T and coronary artery disease risk in heterozygote model and dominant model. In conclusion, our meta-analysis suggested that the CYP2J2 G-50T polymorphism was associated with coronary artery disease risk in the allele, homozygote and recessive models in Caucasians. Impact Journals LLC 2017-07-24 /pmc/articles/PMC5601761/ /pubmed/28938665 http://dx.doi.org/10.18632/oncotarget.19518 Text en Copyright: © 2017 Chen et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Meta-Analysis Chen, Jian Wang, Dong-Fei Fu, Guo-Dong Ding, Jie Chen, Lei-Yang Lv, Jia-Lan Fang, Juan Yin, Xiang Guo, Xiao-Gang Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease |
title | Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease |
title_full | Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease |
title_fullStr | Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease |
title_full_unstemmed | Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease |
title_short | Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease |
title_sort | meta-analysis of the association of the cyp2j2 g-50t polymorphism with coronary artery disease |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601761/ https://www.ncbi.nlm.nih.gov/pubmed/28938665 http://dx.doi.org/10.18632/oncotarget.19518 |
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