Preclinical evidence of ghrelin as a therapeutic target in epilepsy

Ghrelin, an orexigenic peptide synthesized by endocrine cells of the gastric mucosa, plays a major role in inhibiting seizures. However, the underlying mechanism of ghrelin's anticonvulsant action is still unclear. Nowadays, there are considerable evidences showing that ghrelin is implicated in...

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Detalles Bibliográficos
Autores principales: Ge, Tongtong, Yang, Wei, Fan, Jie, Li, Bingjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601790/
https://www.ncbi.nlm.nih.gov/pubmed/28938694
http://dx.doi.org/10.18632/oncotarget.18349
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author Ge, Tongtong
Yang, Wei
Fan, Jie
Li, Bingjin
author_facet Ge, Tongtong
Yang, Wei
Fan, Jie
Li, Bingjin
author_sort Ge, Tongtong
collection PubMed
description Ghrelin, an orexigenic peptide synthesized by endocrine cells of the gastric mucosa, plays a major role in inhibiting seizures. However, the underlying mechanism of ghrelin's anticonvulsant action is still unclear. Nowadays, there are considerable evidences showing that ghrelin is implicated in various neurophysiological processes, including learning and memory, neuroprotection, neurogenesis, and inflammatory effects. In this review, we will summarize the effects of ghrelin on epilepsy. It may provide a comprehensive picture of the role of ghrelin in epilepsy.
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spelling pubmed-56017902017-09-21 Preclinical evidence of ghrelin as a therapeutic target in epilepsy Ge, Tongtong Yang, Wei Fan, Jie Li, Bingjin Oncotarget Review Ghrelin, an orexigenic peptide synthesized by endocrine cells of the gastric mucosa, plays a major role in inhibiting seizures. However, the underlying mechanism of ghrelin's anticonvulsant action is still unclear. Nowadays, there are considerable evidences showing that ghrelin is implicated in various neurophysiological processes, including learning and memory, neuroprotection, neurogenesis, and inflammatory effects. In this review, we will summarize the effects of ghrelin on epilepsy. It may provide a comprehensive picture of the role of ghrelin in epilepsy. Impact Journals LLC 2017-06-02 /pmc/articles/PMC5601790/ /pubmed/28938694 http://dx.doi.org/10.18632/oncotarget.18349 Text en Copyright: © 2017 Ge et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Ge, Tongtong
Yang, Wei
Fan, Jie
Li, Bingjin
Preclinical evidence of ghrelin as a therapeutic target in epilepsy
title Preclinical evidence of ghrelin as a therapeutic target in epilepsy
title_full Preclinical evidence of ghrelin as a therapeutic target in epilepsy
title_fullStr Preclinical evidence of ghrelin as a therapeutic target in epilepsy
title_full_unstemmed Preclinical evidence of ghrelin as a therapeutic target in epilepsy
title_short Preclinical evidence of ghrelin as a therapeutic target in epilepsy
title_sort preclinical evidence of ghrelin as a therapeutic target in epilepsy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601790/
https://www.ncbi.nlm.nih.gov/pubmed/28938694
http://dx.doi.org/10.18632/oncotarget.18349
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AT libingjin preclinicalevidenceofghrelinasatherapeutictargetinepilepsy

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