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A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4

The chemokine receptor CCR7 drives leukocyte migration into and within lymph nodes (LNs). It is activated by chemokines CCL19 and CCL21, which are scavenged by the atypical chemokine receptor ACKR4. CCR7-dependent navigation is determined by the distribution of extracellular CCL19 and CCL21, which f...

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Detalles Bibliográficos
Autores principales:	Jafarnejad, Mohammad, Zawieja, David C., Brook, Bindi S., Nibbs, Robert J. B., Moore, James E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AAI 2017
Materias:	Immune Regulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602158/ https://www.ncbi.nlm.nih.gov/pubmed/28807994 http://dx.doi.org/10.4049/jimmunol.1700377

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