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Metal organic frameworks as a drug delivery system for flurbiprofen
BACKGROUND: Metal organic frameworks (MOFs) have attracted more attention in the last decade because of a suitable pore size, large surface area, and high pore volume. Developing biocompatible MOFs such as the MIL family as a drug delivery system is possible. PURPOSE: Flurbiprofen (FBP), a nonsteroi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602417/ https://www.ncbi.nlm.nih.gov/pubmed/28979098 http://dx.doi.org/10.2147/DDDT.S145716 |
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author | AL Haydar, Muder Abid, Hussein Rasool Sunderland, Bruce Wang, Shaobin |
author_facet | AL Haydar, Muder Abid, Hussein Rasool Sunderland, Bruce Wang, Shaobin |
author_sort | AL Haydar, Muder |
collection | PubMed |
description | BACKGROUND: Metal organic frameworks (MOFs) have attracted more attention in the last decade because of a suitable pore size, large surface area, and high pore volume. Developing biocompatible MOFs such as the MIL family as a drug delivery system is possible. PURPOSE: Flurbiprofen (FBP), a nonsteroidal anti-inflammatory agent, is practically insoluble in aqueous solution, and, therefore, needs suitable drug delivery systems. Different biocompatible MOFs such as Ca-MOF and Fe-MILs (53, 100, and 101) were synthesized and employed for FBP delivery. PATIENTS AND METHODS: A sample of 50 mg of each MOF was mixed and stirred for 24 h with 10 mL of 5 mg FBP in acetonitrile (40%) in a sealed container. The supernatant of the mixture after centrifuging was analyzed by high-performance liquid chromatography to determine the loaded quantity of FBP on the MOF. The overnight-dried solid material after centrifuging the mixture was analyzed for loading percent using X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, nuclear magnetic resonance, and FBP release profile. RESULTS: The loading values of FBP were achieved at 10.0%±1%, 20%±0.8%, 37%±2.3%, and 46%±3.1% on Ca-MOF, Fe-MIL-53, Fe-MIL-101, and Fe-MIL-100, respectively. The FBP release profiles were investigated in a phosphate buffer solution at pH 7.4. The total release of the FBP after 2 days was obtained at 72.9, 75.2, 78.3, and 90.3% for Ca-MOF, Fe-MIL-100, Fe-MIL-53, and Fe-MIL-101, respectively. CONCLUSION: The MOFs are shown to be a promising drug delivery option for FBP with a significant loading percent and relatively prolonged drug release. |
format | Online Article Text |
id | pubmed-5602417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-56024172017-10-04 Metal organic frameworks as a drug delivery system for flurbiprofen AL Haydar, Muder Abid, Hussein Rasool Sunderland, Bruce Wang, Shaobin Drug Des Devel Ther Original Research BACKGROUND: Metal organic frameworks (MOFs) have attracted more attention in the last decade because of a suitable pore size, large surface area, and high pore volume. Developing biocompatible MOFs such as the MIL family as a drug delivery system is possible. PURPOSE: Flurbiprofen (FBP), a nonsteroidal anti-inflammatory agent, is practically insoluble in aqueous solution, and, therefore, needs suitable drug delivery systems. Different biocompatible MOFs such as Ca-MOF and Fe-MILs (53, 100, and 101) were synthesized and employed for FBP delivery. PATIENTS AND METHODS: A sample of 50 mg of each MOF was mixed and stirred for 24 h with 10 mL of 5 mg FBP in acetonitrile (40%) in a sealed container. The supernatant of the mixture after centrifuging was analyzed by high-performance liquid chromatography to determine the loaded quantity of FBP on the MOF. The overnight-dried solid material after centrifuging the mixture was analyzed for loading percent using X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, nuclear magnetic resonance, and FBP release profile. RESULTS: The loading values of FBP were achieved at 10.0%±1%, 20%±0.8%, 37%±2.3%, and 46%±3.1% on Ca-MOF, Fe-MIL-53, Fe-MIL-101, and Fe-MIL-100, respectively. The FBP release profiles were investigated in a phosphate buffer solution at pH 7.4. The total release of the FBP after 2 days was obtained at 72.9, 75.2, 78.3, and 90.3% for Ca-MOF, Fe-MIL-100, Fe-MIL-53, and Fe-MIL-101, respectively. CONCLUSION: The MOFs are shown to be a promising drug delivery option for FBP with a significant loading percent and relatively prolonged drug release. Dove Medical Press 2017-09-11 /pmc/articles/PMC5602417/ /pubmed/28979098 http://dx.doi.org/10.2147/DDDT.S145716 Text en © 2017 AL Haydar et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research AL Haydar, Muder Abid, Hussein Rasool Sunderland, Bruce Wang, Shaobin Metal organic frameworks as a drug delivery system for flurbiprofen |
title | Metal organic frameworks as a drug delivery system for flurbiprofen |
title_full | Metal organic frameworks as a drug delivery system for flurbiprofen |
title_fullStr | Metal organic frameworks as a drug delivery system for flurbiprofen |
title_full_unstemmed | Metal organic frameworks as a drug delivery system for flurbiprofen |
title_short | Metal organic frameworks as a drug delivery system for flurbiprofen |
title_sort | metal organic frameworks as a drug delivery system for flurbiprofen |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602417/ https://www.ncbi.nlm.nih.gov/pubmed/28979098 http://dx.doi.org/10.2147/DDDT.S145716 |
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