Palonosetron-Induced Ventricular Tachycardia in a Patient Receiving Cancer Chemotherapy

Chemotherapy-induced nausea and vomiting (CINV) is one of the major and most distressing adverse effects of cancer chemotherapy. It is treated with various antiemetic regimens, of which one class of drugs is 5-hydroxytryptamine type 3 receptor antagonists (5-HT(3) RA). Palonosetron, a potent antieme...

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Detalles Bibliográficos
Autores principales: M, Prasad, V K, Shashidar, Chakraborty, Ananya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2017
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602430/
https://www.ncbi.nlm.nih.gov/pubmed/28944119
http://dx.doi.org/10.7759/cureus.1480
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author M, Prasad
V K, Shashidar
Chakraborty, Ananya
author_facet M, Prasad
V K, Shashidar
Chakraborty, Ananya
author_sort M, Prasad
collection PubMed
description Chemotherapy-induced nausea and vomiting (CINV) is one of the major and most distressing adverse effects of cancer chemotherapy. It is treated with various antiemetic regimens, of which one class of drugs is 5-hydroxytryptamine type 3 receptor antagonists (5-HT(3) RA). Palonosetron, a potent antiemetic, is a second generation 5-HT(3) RA. All 5-HT(3) antagonists, except palonosetron, have been reported to cause corrected QT interval (QTc) prolongation and certain arrhythmias. Here, we report a case of palonosetron-induced ventricular tachycardia in a 45-year-old patient receiving cancer chemotherapy.
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spelling pubmed-56024302017-09-22 Palonosetron-Induced Ventricular Tachycardia in a Patient Receiving Cancer Chemotherapy M, Prasad V K, Shashidar Chakraborty, Ananya Cureus Oncology Chemotherapy-induced nausea and vomiting (CINV) is one of the major and most distressing adverse effects of cancer chemotherapy. It is treated with various antiemetic regimens, of which one class of drugs is 5-hydroxytryptamine type 3 receptor antagonists (5-HT(3) RA). Palonosetron, a potent antiemetic, is a second generation 5-HT(3) RA. All 5-HT(3) antagonists, except palonosetron, have been reported to cause corrected QT interval (QTc) prolongation and certain arrhythmias. Here, we report a case of palonosetron-induced ventricular tachycardia in a 45-year-old patient receiving cancer chemotherapy. Cureus 2017-07-17 /pmc/articles/PMC5602430/ /pubmed/28944119 http://dx.doi.org/10.7759/cureus.1480 Text en Copyright © 2017, M et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Oncology
M, Prasad
V K, Shashidar
Chakraborty, Ananya
Palonosetron-Induced Ventricular Tachycardia in a Patient Receiving Cancer Chemotherapy
title Palonosetron-Induced Ventricular Tachycardia in a Patient Receiving Cancer Chemotherapy
title_full Palonosetron-Induced Ventricular Tachycardia in a Patient Receiving Cancer Chemotherapy
title_fullStr Palonosetron-Induced Ventricular Tachycardia in a Patient Receiving Cancer Chemotherapy
title_full_unstemmed Palonosetron-Induced Ventricular Tachycardia in a Patient Receiving Cancer Chemotherapy
title_short Palonosetron-Induced Ventricular Tachycardia in a Patient Receiving Cancer Chemotherapy
title_sort palonosetron-induced ventricular tachycardia in a patient receiving cancer chemotherapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602430/
https://www.ncbi.nlm.nih.gov/pubmed/28944119
http://dx.doi.org/10.7759/cureus.1480
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AT chakrabortyananya palonosetroninducedventriculartachycardiainapatientreceivingcancerchemotherapy

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