Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients()

This is the first prospective study of the effects of human gut microbiota and metabolites on immune checkpoint inhibitor (ICT) response in metastatic melanoma patients. Whereas many melanoma patients exhibit profound response to ICT, there are fewer options for patients failing ICT—particularly wit...

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Detalles Bibliográficos
Autores principales: Frankel, Arthur E., Coughlin, Laura A., Kim, Jiwoong, Froehlich, Thomas W., Xie, Yang, Frenkel, Eugene P., Koh, Andrew Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2017
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602478/
https://www.ncbi.nlm.nih.gov/pubmed/28923537
http://dx.doi.org/10.1016/j.neo.2017.08.004

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