Cargando…

Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway

Fibrosis is the major pathological feature of diabetic kidney disease (DKD). Autophagy, a process to maintain metabolic homeostasis, is obviously inhibited in DKD. Triptolide (TP) is a traditional Chinese medicine extract known for immune suppression and anti-inflammatory and anti-cancer activities....

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xiao-yu, Wang, Shan-shan, Han, Zhe, Han, Fei, Chang, Yun-peng, Yang, Yang, Xue, Mei, Sun, Bei, Chen, Li-ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602517/ https://www.ncbi.nlm.nih.gov/pubmed/29246323 http://dx.doi.org/10.1016/j.omtn.2017.08.011

Ejemplares similares

Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway
por: Han, Fei, et al.
Publicado: (2017)

Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway
por: Li, Liuran, et al.
Publicado: (2021)

Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway: Erratum
por: Han, Fei, et al.
Publicado: (2020)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

YAP manipulates proliferation via PTEN/AKT/mTOR-mediated autophagy in lung adenocarcinomas
por: Xu, Wei, et al.
Publicado: (2021)

Triptolide Induces Glioma Cell Autophagy and Apoptosis via Upregulating the ROS/JNK and Downregulating the Akt/mTOR Signaling Pathways
por: Liu, Xihong, et al.
Publicado: (2019)

Calcium Dobesilate Restores Autophagy by Inhibiting the VEGF/PI3K/AKT/mTOR Signaling Pathway
por: Wang, Yue, et al.
Publicado: (2019)

Mingmu Xiaomeng Tablets Restore Autophagy and Alleviate Diabetic Retinopathy by Inhibiting PI3K/Akt/mTOR Signaling
por: Fang, Yuwei, et al.
Publicado: (2021)

Antagonizing circRNA_002581–miR-122–CPEB1 axis alleviates NASH through restoring PTEN–AMPK–mTOR pathway regulated autophagy
por: Jin, Xi, et al.
Publicado: (2020)

Tetrahydrofolate Alleviates the Inhibitory Effect of Oxidative Stress on Neural Stem Cell Proliferation through PTEN/Akt/mTOR Pathway
por: Zhang, Xuyang, et al.
Publicado: (2022)

Neuroprotective effects of DAHP and Triptolide in focal cerebral ischemia via apoptosis inhibition and PI3K/Akt/mTOR pathway activation
por: Li, Weiyun, et al.
Publicado: (2015)

Mycoplasma bovis inhibits autophagy in bovine mammary epithelial cells via a PTEN/PI3K-Akt-mTOR-dependent pathway
por: Xu, Maolin, et al.
Publicado: (2022)

MAF1 suppresses AKT‐mTOR signaling and liver cancer through activation of PTEN transcription
por: Li, Yue, et al.
Publicado: (2016)

MiR-146b inhibits autophagy in prostate cancer by targeting the PTEN/Akt/mTOR signaling pathway
por: Gao, Song, et al.
Publicado: (2018)

Berberine Reverses Doxorubicin Resistance by Inhibiting Autophagy Through the PTEN/Akt/mTOR Signaling Pathway in Breast Cancer
por: Wang, Ye, et al.
Publicado: (2020)

Icariin alleviates osteoarthritis by regulating autophagy of chondrocytes by mediating PI3K/AKT/mTOR signaling
por: Tang, Yanghua, et al.
Publicado: (2021)

Dihydroartemisinin Induces Endothelial Cell Autophagy through Suppression of the Akt/mTOR Pathway
por: Liu, Jing, et al.
Publicado: (2019)

BMSC-Derived Exosomes Alleviate Intervertebral Disc Degeneration by Modulating AKT/mTOR-Mediated Autophagy of Nucleus Pulposus Cells
por: Xiao, Quan, et al.
Publicado: (2022)

Xanthohumol alleviates oxidative stress and impaired autophagy in experimental severe acute pancreatitis through inhibition of AKT/mTOR
por: Huangfu, Yaru, et al.
Publicado: (2023)

miR-214 ameliorates sepsis-induced acute kidney injury via PTEN/AKT/mTOR-regulated autophagy
por: Sang, Zhenzhen, et al.
Publicado: (2021)

Berberine Reverses Doxorubicin Resistance by Inhibiting Autophagy Through the PTEN/Akt/mTOR Signaling Pathway in Breast Cancer [Retraction]
Publicado: (2023)

Gypenosides Attenuate Pulmonary Fibrosis by Inhibiting the AKT/mTOR/c-Myc Pathway
por: Liu, Suqing, et al.
Publicado: (2022)

COX-2/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy through Sirt1/PI3K/AKT/mTOR
por: Zhang, Chen-Yu, et al.
Publicado: (2022)

MicroRNA‐221 promotes breast cancer resistance to adriamycin via modulation of PTEN/Akt/mTOR signaling
por: Yin, Yingchun, et al.
Publicado: (2020)

ARNTL inhibits the malignant behaviors of oral cancer by regulating autophagy in an AKT/mTOR pathway‐dependent manner
por: Chen, KuiChi, et al.
Publicado: (2023)

E2F7−EZH2 axis regulates PTEN/AKT/mTOR signalling and glioblastoma progression
por: Yang, Rui, et al.
Publicado: (2020)

Correction: MiR-146b inhibits autophagy in prostate cancer through affecting PTEN/AKT/mTOR signaling pathway
por: Gao, Song, et al.
Publicado: (2019)

Tripartite motif 27 promotes cardiac hypertrophy via PTEN/Akt/mTOR signal pathways
por: Chen, Yan, et al.
Publicado: (2022)

Sodium cantharidate promotes autophagy in breast cancer cells by inhibiting the PI3K–Akt–mTOR signaling pathway
por: Pang, Jin-Long, et al.
Publicado: (2022)

Matrine induces autophagy in human neuroblastoma cells via blocking the AKT-mTOR pathway
por: Liu, Nanjing, et al.
Publicado: (2022)

PTEN/AKT/mTOR signaling mediates anticancer effects of epigallocatechin-3-gallate in ovarian cancer
por: Qin, Jianli, et al.
Publicado: (2020)

Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways
por: Lu, Rui, et al.
Publicado: (2023)

ATGL deficiency aggravates pressure overload-triggered myocardial hypertrophic remodeling associated with the proteasome-PTEN-mTOR-autophagy pathway
por: Han, Xiao, et al.
Publicado: (2022)

LncRNA MEG3 inhibits rheumatoid arthritis through miR‐141 and inactivation of AKT/mTOR signalling pathway
por: Li, Guoqing, et al.
Publicado: (2019)

HDAC6, modulated by miR-206, promotes endometrial cancer progression through the PTEN/AKT/mTOR pathway
por: Zheng, Yawen, et al.
Publicado: (2020)

Genetic Variations in a PTEN/AKT/mTOR Axis and Prostate Cancer Risk in a Chinese Population
por: Chen, Jiawei, et al.
Publicado: (2012)

Valproic Acid Enhanced Apoptosis by Promoting Autophagy Via Akt/mTOR Signaling in Glioma
por: Han, Wei, et al.
Publicado: (2020)

miR-149 Alleviates Ox-LDL-Induced Endothelial Cell Injury by Promoting Autophagy through Akt/mTOR Pathway
por: Zhu, Zhongsheng, et al.
Publicado: (2021)

Limb Remote Ischemic Conditioning Promotes Myelination by Upregulating PTEN/Akt/mTOR Signaling Activities after Chronic Cerebral Hypoperfusion
por: Li, Xiaohua, et al.
Publicado: (2017)

Ursolic Acid Attenuates Diabetic Mesangial Cell Injury through the Up-Regulation of Autophagy via miRNA-21/PTEN/Akt/mTOR Suppression
por: Lu, Xinxing, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_63jqgocmnm3gvtuudlo6e6k23k