Cargando…

Targeted inhibition of the phosphoinositide 3-kinase impairs cell proliferation, survival, and invasion in colon cancer

BACKGROUND: Colon cancer is the third most common cancer in the world, and its metastasis and drug resistance are challenging for its effective treatment. The PI3K/Akt/mTOR pathway plays a crucial role in the pathogenesis of colon cancer. The aim of this study was to investigate the targeting of PI3...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Fei, Gao, Jun-Yi, Chen, Hua, Du, Zhen-Hua, Zhang, Xue-Qun, Gao, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602681/ https://www.ncbi.nlm.nih.gov/pubmed/28979133 http://dx.doi.org/10.2147/OTT.S145601

Ejemplares similares

Fucoidan inhibits the migration and proliferation of HT-29 human colon cancer cells via the phosphoinositide-3 kinase/Akt/mechanistic target of rapamycin pathways
por: HAN, YONG-SEOK, et al.
Publicado: (2015)

Casticin inhibits nasopharyngeal carcinoma growth by targeting phosphoinositide 3-kinase
por: Liu, Jingxian, et al.
Publicado: (2019)

Correction to: Casticin inhibits nasopharyngeal carcinoma growth by targeting phosphoinositide 3-kinase
por: Liu, Jingxian, et al.
Publicado: (2021)

Phosphoinositide-3-Kinase Is the Primary Mediator of Phosphoinositide-Dependent Inhibition in Mammalian Olfactory Receptor Neurons
por: Ukhanov, Kirill, et al.
Publicado: (2016)

Psoriasiform eruptions secondary to phosphoinositide 3-kinase inhibition
por: Dewan, Anna K., et al.
Publicado: (2019)

Phosphoinositide 3-Kinase signaling pathway: the key to cell proliferation and death
por: Peacock, Justin
Publicado: (2007)

MicroRNA-7 inhibits colorectal cancer cell proliferation, migration and invasion via TYRO3 and phosphoinositide 3-kinase/protein B kinase/mammalian target of rapamycin pathway suppression
por: Qin, Ancheng, et al.
Publicado: (2018)

Phosphoinositide 3-Kinases as Potential Targets for Thrombosis Prevention
por: Setiabakti, Natasha M., et al.
Publicado: (2022)

Overexpression of N-myc downstream-regulated gene 1 inhibits human glioma proliferation and invasion via phosphoinositide 3-kinase/AKT pathways
por: MA, WEI, et al.
Publicado: (2015)

DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway
por: Lu, Ting, et al.
Publicado: (2019)

MAGI1 Inhibits the Proliferation, Migration and Invasion of Glioma Cells
por: Li, Zhong-Yan, et al.
Publicado: (2019)

Activation of Myocardial Phosphoinositide-3-Kinase p110α Ameliorates Cardiac Dysfunction and Improves Survival in Polymicrobial Sepsis
por: Li, Chuanfu, et al.
Publicado: (2012)

Protein Kinase Activity of Phosphoinositide 3-Kinase Regulates Cytokine-Dependent Cell Survival
por: Thomas, Daniel, et al.
Publicado: (2013)

Targeted polypharmacology: Discovery of dual inhibitors of tyrosine and phosphoinositide kinases
por: Apsel, Beth, et al.
Publicado: (2008)

Targeting phosphoinositide 3-kinases and histone deacetylases in multiple myeloma
por: Okabe, Seiichi, et al.
Publicado: (2021)

Beyond PI3Ks: targeting phosphoinositide kinases in disease
por: Burke, John E., et al.
Publicado: (2022)

Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK)
por: Huang, Xueqin, et al.
Publicado: (2023)

Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides
por: Xu, Jun, et al.
Publicado: (2001)

MicroRNA-375 targets the 3-phosphoinositide-dependent protein kinase-1 gene in pancreatic carcinoma
por: SONG, SHI-DUO, et al.
Publicado: (2013)

Targeting the phosphoinositide-3-kinase/protein kinase B pathway in airway innate immunity
por: Gopallawa, Indiwari, et al.
Publicado: (2020)

Tetramethylpyrazine inhibits proliferation of colon cancer cells in vitro
por: Li, Hua, et al.
Publicado: (2021)

Telocinobufagin inhibits the epithelial-mesenchymal transition of breast cancer cells through the phosphoinositide 3-kinase/protein kinase B/extracellular signal-regulated kinase/Snail signaling pathway
por: Gao, Yuxue, et al.
Publicado: (2018)

Xihuang pills induce apoptosis in hepatocellular carcinoma by suppressing phosphoinositide 3-kinase/protein kinase-B/mechanistic target of rapamycin pathway
por: Teng, Yong-Jie, et al.
Publicado: (2022)

Resveratrol inhibits hypoxia-induced proliferation and migration of pulmonary artery vascular smooth muscle cells by inhibiting the phosphoinositide 3-kinase/protein kinase B signaling pathway
por: Guan, Zhanjiang, et al.
Publicado: (2017)

The 3-Phosphoinositide-Dependent Protein Kinase 1 Inhibits Rod Photoreceptor Development
por: Xing, Tiaosi, et al.
Publicado: (2018)

The Inhibition of Phosphoinositide-3 Kinases Induce Resolution of Inflammation in a Gout Model
por: Galvão, Izabela, et al.
Publicado: (2019)

Lipopolysaccharide Induces Lung Fibroblast Proliferation through Toll-Like Receptor 4 Signaling and the Phosphoinositide3-Kinase-Akt Pathway
por: He, Zhengyu, et al.
Publicado: (2012)

Phosphoinositide 3-Kinase Inhibitor-Induced Hyperglycemia
por: Shey, Susan, et al.
Publicado: (2021)

Regulation of heart rate and the pacemaker current by phosphoinositide 3-kinase signaling
por: Lin, Richard Z., et al.
Publicado: (2019)

Inhibition of the phosphoinositide 3-kinase pathway decreases innate resistance to lipopolysaccharide toxicity in TLR4 deficient mice
por: Yang, Johnson Chia-Shen, et al.
Publicado: (2014)

Upregulation of microRNA-383 inhibits the proliferation, migration and invasion of colon cancer cells
por: Cui, Ying, et al.
Publicado: (2018)

Phosphoinositide 3-Kinase Promotes Oxidative Burst, Stomatal Closure and Plant Immunity in Bacterial Invasion
por: Zhang, Huiying, et al.
Publicado: (2020)

Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4
por: Nirula, Ajay, et al.
Publicado: (2006)

MicroRNA-432 is downregulated in osteosarcoma and inhibits cell proliferation and invasion by directly targeting metastasis-associated in colon cancer-1
por: Lv, Dengkun, et al.
Publicado: (2022)

Synergistic inhibition of colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002
por: Cai, Xinyi, et al.
Publicado: (2015)

Phosphoinositide-3 Kinase Inhibition Modulates Responses to Rhinovirus by Mechanisms that Are Predominantly Independent of Autophagy
por: Ismail, Saila, et al.
Publicado: (2014)

Tyrosol Suppresses Allergic Inflammation by Inhibiting the Activation of Phosphoinositide 3-Kinase in Mast Cells
por: Je, In-Gyu, et al.
Publicado: (2015)

Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer
por: Emmanouilidi, Aikaterini, et al.
Publicado: (2019)

Sodium-Glucose Cotransporter-2 Inhibitors for Hyperglycemia in Phosphoinositide 3-kinase Pathway Inhibition
por: Weintraub, Michael A, et al.
Publicado: (2023)

Antithrombin III Alleviates Myocardial Ischemia/Reperfusion Injury by Inhibiting Excessive Autophagy in a Phosphoinositide 3-Kinase/Akt-Dependent Manner
por: Huang, Kai-yu, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3phu1etg7rjp5n8iinohj9gbum