Rod metabolic demand drives progression in retinopathies

Various factors are thought to cause the development and progression of disease in macular degeneration, diabetic retinopathy, and retinitis pigmentosa. Some of the deleterious processes include oxidative stress, hypoxia, metabolic derangement, genetics, and vasculopathy. In this review, we present...

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Detalles Bibliográficos
Autores principales: Lin, Michael K., Kim, Soo Hyun, Zhang, Lijuan, Tsai, Yi-Ting, Tsang, Stephen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602704/
https://www.ncbi.nlm.nih.gov/pubmed/29018679
http://dx.doi.org/10.1016/j.tjo.2015.06.002
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author Lin, Michael K.
Kim, Soo Hyun
Zhang, Lijuan
Tsai, Yi-Ting
Tsang, Stephen H.
author_facet Lin, Michael K.
Kim, Soo Hyun
Zhang, Lijuan
Tsai, Yi-Ting
Tsang, Stephen H.
author_sort Lin, Michael K.
collection PubMed
description Various factors are thought to cause the development and progression of disease in macular degeneration, diabetic retinopathy, and retinitis pigmentosa. Some of the deleterious processes include oxidative stress, hypoxia, metabolic derangement, genetics, and vasculopathy. In this review, we present a unified theory for the pathophysiology of several retinopathies based on the unique and intense metabolism of rod photoreceptors.
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spelling pubmed-56027042017-10-10 Rod metabolic demand drives progression in retinopathies Lin, Michael K. Kim, Soo Hyun Zhang, Lijuan Tsai, Yi-Ting Tsang, Stephen H. Taiwan J Ophthalmol Review Article Various factors are thought to cause the development and progression of disease in macular degeneration, diabetic retinopathy, and retinitis pigmentosa. Some of the deleterious processes include oxidative stress, hypoxia, metabolic derangement, genetics, and vasculopathy. In this review, we present a unified theory for the pathophysiology of several retinopathies based on the unique and intense metabolism of rod photoreceptors. Medknow Publications & Media Pvt Ltd 2015 2015-08-25 /pmc/articles/PMC5602704/ /pubmed/29018679 http://dx.doi.org/10.1016/j.tjo.2015.06.002 Text en Copyright: © 2015, The Ophthalmologic Society of Taiwan http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Lin, Michael K.
Kim, Soo Hyun
Zhang, Lijuan
Tsai, Yi-Ting
Tsang, Stephen H.
Rod metabolic demand drives progression in retinopathies
title Rod metabolic demand drives progression in retinopathies
title_full Rod metabolic demand drives progression in retinopathies
title_fullStr Rod metabolic demand drives progression in retinopathies
title_full_unstemmed Rod metabolic demand drives progression in retinopathies
title_short Rod metabolic demand drives progression in retinopathies
title_sort rod metabolic demand drives progression in retinopathies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602704/
https://www.ncbi.nlm.nih.gov/pubmed/29018679
http://dx.doi.org/10.1016/j.tjo.2015.06.002
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