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Early assessment of response to induction therapy in acute myeloid leukemia using (18)F-FLT PET/CT

BACKGROUND: We evaluated the suitability of (18)F-fluorodeoxythymidine ((18)F-FLT) positron emission tomography (PET)/computed tomography (CT) for assessment of the early response to induction therapy and its value for predicting clinical outcome in patients with acute myeloid leukemia (AML). Adult...

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Autores principales: Han, Eun Ji, Lee, Bo-hee, Kim, Jeong-A, Park, Young Ha, Choi, Woo Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602811/
https://www.ncbi.nlm.nih.gov/pubmed/28916904
http://dx.doi.org/10.1186/s13550-017-0326-8
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author Han, Eun Ji
Lee, Bo-hee
Kim, Jeong-A
Park, Young Ha
Choi, Woo Hee
author_facet Han, Eun Ji
Lee, Bo-hee
Kim, Jeong-A
Park, Young Ha
Choi, Woo Hee
author_sort Han, Eun Ji
collection PubMed
description BACKGROUND: We evaluated the suitability of (18)F-fluorodeoxythymidine ((18)F-FLT) positron emission tomography (PET)/computed tomography (CT) for assessment of the early response to induction therapy and its value for predicting clinical outcome in patients with acute myeloid leukemia (AML). Adult patients who had histologically confirmed AML and received induction therapy were enrolled. All patients underwent (18)F-FLT PET/CT after completion of induction. PET/CT images were visually and quantitatively assessed. Cases with intensely increased bone marrow uptake in more than one third of the long bones and throughout the central skeleton were interpreted as PET-positive for resistant disease (RD). PET results were compared to the clinical response and outcome. RESULTS: In visual PET analysis of 10 eligible patients (7 male, 3 female; median age 58 years), 5 patients were interpreted as being PET-positive and 5 as PET-negative. Standardized uptake values were significantly different between PET-positive and PET-negative groups. Eight of 10 patients achieved clinical complete remission (CR)/CR with incomplete blood count recovery (CRi). Five CR/CRi patients had PET-negative findings, but 3 CR patients had PET-positive findings. Both of the RD patients had PET-positive findings. During follow-up, 2 CR patients with PET-positive findings relapsed, or were strongly suspected of relapse, 4 months after consolidation. CONCLUSION: (18)F-FLT PET/CT after induction therapy showed good sensitivity and negative-predictive value for evaluating RD in patients with AML. This preliminary study suggests that (18)F-FLT PET/CT may be valuable as a noninvasive tool for early assessment of the response to treatment and may provide prognostic value for survival in patients with AML.
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spelling pubmed-56028112017-09-27 Early assessment of response to induction therapy in acute myeloid leukemia using (18)F-FLT PET/CT Han, Eun Ji Lee, Bo-hee Kim, Jeong-A Park, Young Ha Choi, Woo Hee EJNMMI Res Original Research BACKGROUND: We evaluated the suitability of (18)F-fluorodeoxythymidine ((18)F-FLT) positron emission tomography (PET)/computed tomography (CT) for assessment of the early response to induction therapy and its value for predicting clinical outcome in patients with acute myeloid leukemia (AML). Adult patients who had histologically confirmed AML and received induction therapy were enrolled. All patients underwent (18)F-FLT PET/CT after completion of induction. PET/CT images were visually and quantitatively assessed. Cases with intensely increased bone marrow uptake in more than one third of the long bones and throughout the central skeleton were interpreted as PET-positive for resistant disease (RD). PET results were compared to the clinical response and outcome. RESULTS: In visual PET analysis of 10 eligible patients (7 male, 3 female; median age 58 years), 5 patients were interpreted as being PET-positive and 5 as PET-negative. Standardized uptake values were significantly different between PET-positive and PET-negative groups. Eight of 10 patients achieved clinical complete remission (CR)/CR with incomplete blood count recovery (CRi). Five CR/CRi patients had PET-negative findings, but 3 CR patients had PET-positive findings. Both of the RD patients had PET-positive findings. During follow-up, 2 CR patients with PET-positive findings relapsed, or were strongly suspected of relapse, 4 months after consolidation. CONCLUSION: (18)F-FLT PET/CT after induction therapy showed good sensitivity and negative-predictive value for evaluating RD in patients with AML. This preliminary study suggests that (18)F-FLT PET/CT may be valuable as a noninvasive tool for early assessment of the response to treatment and may provide prognostic value for survival in patients with AML. Springer Berlin Heidelberg 2017-09-16 /pmc/articles/PMC5602811/ /pubmed/28916904 http://dx.doi.org/10.1186/s13550-017-0326-8 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Han, Eun Ji
Lee, Bo-hee
Kim, Jeong-A
Park, Young Ha
Choi, Woo Hee
Early assessment of response to induction therapy in acute myeloid leukemia using (18)F-FLT PET/CT
title Early assessment of response to induction therapy in acute myeloid leukemia using (18)F-FLT PET/CT
title_full Early assessment of response to induction therapy in acute myeloid leukemia using (18)F-FLT PET/CT
title_fullStr Early assessment of response to induction therapy in acute myeloid leukemia using (18)F-FLT PET/CT
title_full_unstemmed Early assessment of response to induction therapy in acute myeloid leukemia using (18)F-FLT PET/CT
title_short Early assessment of response to induction therapy in acute myeloid leukemia using (18)F-FLT PET/CT
title_sort early assessment of response to induction therapy in acute myeloid leukemia using (18)f-flt pet/ct
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602811/
https://www.ncbi.nlm.nih.gov/pubmed/28916904
http://dx.doi.org/10.1186/s13550-017-0326-8
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