Lacosamide for refractory generalized tonic–clonic seizures of non-focal origin in clinical practice: A clinical and VEEG study

• 7 of 9 patients with GGE reduced ≥ 50% their tonic–clonic seizure frequency on LCM. • All 7 patients remained seizure free for > 1 year, and 2 of them for > 5 years. • In 2 of the 9 patients, both with Juvenile Absence Epilepsy, absences aggravated. • One aggravation consisted on a myoclonia...

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Detalles Bibliográficos
Autores principales: Abarrategui, Belén, García-García, María Eugenia, Toledano, Rafael, Parejo-Carbonell, Beatriz, Gil-Nagel, Antonio, García-Morales, Irene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602820/
https://www.ncbi.nlm.nih.gov/pubmed/28948142
http://dx.doi.org/10.1016/j.ebcr.2017.08.001
Descripción
Sumario:• 7 of 9 patients with GGE reduced ≥ 50% their tonic–clonic seizure frequency on LCM. • All 7 patients remained seizure free for > 1 year, and 2 of them for > 5 years. • In 2 of the 9 patients, both with Juvenile Absence Epilepsy, absences aggravated. • One aggravation consisted on a myoclonia and absence status, in a patient with no history of myoclonia. • VEEG paralleled clinical improvement but didn't change in a case of absence worsening.

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