A decade of research into classical swine fever marker vaccine CP7_E2alf (Suvaxyn(®) CSF Marker): a review of vaccine properties

Due to its impact on animal health and pig industry, classical swine fever (CSF) is still one of the most important viral diseases of pigs. To control the disease, safe and highly efficacious live attenuated vaccines exist for decades. However, until recently, the available live vaccines did not all...

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Autores principales: Blome, Sandra, Wernike, Kerstin, Reimann, Ilona, König, Patricia, Moß, Claudia, Beer, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603031/
https://www.ncbi.nlm.nih.gov/pubmed/28915927
http://dx.doi.org/10.1186/s13567-017-0457-y
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author Blome, Sandra
Wernike, Kerstin
Reimann, Ilona
König, Patricia
Moß, Claudia
Beer, Martin
author_facet Blome, Sandra
Wernike, Kerstin
Reimann, Ilona
König, Patricia
Moß, Claudia
Beer, Martin
author_sort Blome, Sandra
collection PubMed
description Due to its impact on animal health and pig industry, classical swine fever (CSF) is still one of the most important viral diseases of pigs. To control the disease, safe and highly efficacious live attenuated vaccines exist for decades. However, until recently, the available live vaccines did not allow a serological marker concept that is essentially important to circumvent long-term trade restrictions. In 2014, a new live attenuated marker vaccine, Suvaxyn(®) CSF Marker (Zoetis), was licensed by the European Medicines Agency. This vaccine is based on pestivirus chimera “CP7_E2alf” that carries the main immunogen of CSF virus “Alfort/187”, glycoprotein E2, in a bovine viral diarrhea virus type 1 backbone (“CP7”). This review summarizes the available data on design, safety, efficacy, marker diagnostics, and its possible integration into control strategies.
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spelling pubmed-56030312017-09-20 A decade of research into classical swine fever marker vaccine CP7_E2alf (Suvaxyn(®) CSF Marker): a review of vaccine properties Blome, Sandra Wernike, Kerstin Reimann, Ilona König, Patricia Moß, Claudia Beer, Martin Vet Res Review Due to its impact on animal health and pig industry, classical swine fever (CSF) is still one of the most important viral diseases of pigs. To control the disease, safe and highly efficacious live attenuated vaccines exist for decades. However, until recently, the available live vaccines did not allow a serological marker concept that is essentially important to circumvent long-term trade restrictions. In 2014, a new live attenuated marker vaccine, Suvaxyn(®) CSF Marker (Zoetis), was licensed by the European Medicines Agency. This vaccine is based on pestivirus chimera “CP7_E2alf” that carries the main immunogen of CSF virus “Alfort/187”, glycoprotein E2, in a bovine viral diarrhea virus type 1 backbone (“CP7”). This review summarizes the available data on design, safety, efficacy, marker diagnostics, and its possible integration into control strategies. BioMed Central 2017-09-15 2017 /pmc/articles/PMC5603031/ /pubmed/28915927 http://dx.doi.org/10.1186/s13567-017-0457-y Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Blome, Sandra
Wernike, Kerstin
Reimann, Ilona
König, Patricia
Moß, Claudia
Beer, Martin
A decade of research into classical swine fever marker vaccine CP7_E2alf (Suvaxyn(®) CSF Marker): a review of vaccine properties
title A decade of research into classical swine fever marker vaccine CP7_E2alf (Suvaxyn(®) CSF Marker): a review of vaccine properties
title_full A decade of research into classical swine fever marker vaccine CP7_E2alf (Suvaxyn(®) CSF Marker): a review of vaccine properties
title_fullStr A decade of research into classical swine fever marker vaccine CP7_E2alf (Suvaxyn(®) CSF Marker): a review of vaccine properties
title_full_unstemmed A decade of research into classical swine fever marker vaccine CP7_E2alf (Suvaxyn(®) CSF Marker): a review of vaccine properties
title_short A decade of research into classical swine fever marker vaccine CP7_E2alf (Suvaxyn(®) CSF Marker): a review of vaccine properties
title_sort decade of research into classical swine fever marker vaccine cp7_e2alf (suvaxyn(®) csf marker): a review of vaccine properties
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603031/
https://www.ncbi.nlm.nih.gov/pubmed/28915927
http://dx.doi.org/10.1186/s13567-017-0457-y
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