DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding

BACKGROUND: Genome-wide association studies (GWASs) have identified dozens of loci associated with gout, but for most cases, the risk genes and the underlying molecular mechanisms contributing to these associations are unknown. This study sought to understand the molecular mechanism of a common gene...

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Detalles Bibliográficos
Autores principales: Zhu, Zaihua, Meng, Weida, Liu, Peiru, Zhu, Xiaoxia, Liu, Yun, Zou, Hejian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603049/
https://www.ncbi.nlm.nih.gov/pubmed/28932319
http://dx.doi.org/10.1186/s13148-017-0401-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603049/
https://www.ncbi.nlm.nih.gov/pubmed/28932319
http://dx.doi.org/10.1186/s13148-017-0401-z

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