Anti-fibrotic efficacy of nintedanib in pulmonary fibrosis via the inhibition of fibrocyte activity

BACKGROUND: Nintedanib, a tyrosine kinase inhibitor that is specific for platelet-derived growth factor receptors (PDGFR), fibroblast growth factor receptors (FGFR), and vascular endothelial growth factor receptors (VEGFR), has recently been approved for idiopathic pulmonary fibrosis. Fibrocytes are...

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Detalles Bibliográficos
Autores principales: Sato, Seidai, Shinohara, Shintaro, Hayashi, Shinya, Morizumi, Shun, Abe, Shuichi, Okazaki, Hiroyasu, Chen, Yanjuan, Goto, Hisatsugu, Aono, Yoshinori, Ogawa, Hirohisa, Koyama, Kazuya, Nishimura, Haruka, Kawano, Hiroshi, Toyoda, Yuko, Uehara, Hisanori, Nishioka, Yasuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603061/
https://www.ncbi.nlm.nih.gov/pubmed/28915889
http://dx.doi.org/10.1186/s12931-017-0654-2

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