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Impact of UGT1A1 gene polymorphisms on plasma dolutegravir trough concentrations and neuropsychiatric adverse events in Japanese individuals infected with HIV-1

BACKGROUND: Dolutegravir (DTG) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1), and partly by cytochrome P450 3A (CYP3A). Therefore, we focused on UGT1A1 gene polymorphisms (*6 and *28) in Japanese individuals infected with human immunodeficiency virus (HIV)-1...

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Detalles Bibliográficos
Autores principales:	Yagura, Hiroki, Watanabe, Dai, Kushida, Hiroyuki, Tomishima, Kosuke, Togami, Hiroaki, Hirano, Atsushi, Takahashi, Masaaki, Hirota, Kazuyuki, Ikuma, Motoko, Kasai, Daisuke, Nishida, Yasuharu, Yoshino, Munehiro, Yamazaki, Kunio, Uehira, Tomoko, Shirasaka, Takuma
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603066/ https://www.ncbi.nlm.nih.gov/pubmed/28915895 http://dx.doi.org/10.1186/s12879-017-2717-x

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