Gas Chromatography-Triple Quadrupole Mass Spectrometry Analysis and Vasorelaxant Effect of Essential Oil from Protium heptaphyllum (Aubl.) March.

The Protium heptaphyllum species, also known as Almécega, produces an oily resin, used in folk medicine as an analgesic and anti-inflammatory agent, in healing, and as an expectorant, which is rich in pentacyclic triterpenes and essential oils. In this study, the essential oil obtained by hydrodisti...

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Autores principales: Mobin, Mitra, de Lima, Sidney G., Almeida, Lorena T. G., Silva Filho, José C., Rocha, Márcio S., Oliveira, Aldeídia P., Mendes, Marcelo B., Carvalho, Fernando A. A., Melhem, Marcia S. C., Costa, José G. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603114/
https://www.ncbi.nlm.nih.gov/pubmed/28951867
http://dx.doi.org/10.1155/2017/1928171
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author Mobin, Mitra
de Lima, Sidney G.
Almeida, Lorena T. G.
Silva Filho, José C.
Rocha, Márcio S.
Oliveira, Aldeídia P.
Mendes, Marcelo B.
Carvalho, Fernando A. A.
Melhem, Marcia S. C.
Costa, José G. M.
author_facet Mobin, Mitra
de Lima, Sidney G.
Almeida, Lorena T. G.
Silva Filho, José C.
Rocha, Márcio S.
Oliveira, Aldeídia P.
Mendes, Marcelo B.
Carvalho, Fernando A. A.
Melhem, Marcia S. C.
Costa, José G. M.
author_sort Mobin, Mitra
collection PubMed
description The Protium heptaphyllum species, also known as Almécega, produces an oily resin, used in folk medicine as an analgesic and anti-inflammatory agent, in healing, and as an expectorant, which is rich in pentacyclic triterpenes and essential oils. In this study, the essential oil obtained by hydrodistillation of Almécega's resin was analyzed by gas chromatography-triple quadrupole mass spectrometry and evaluated for chemical composition and vasorelaxant activity in rat superior mesenteric artery. The main constituents determined by gas chromatography-triple quadrupole mass spectrometry were limonene, p-cineole, and o-cymene. In intact rings precontracted with phenylephrine (Phe 1 μM), EOPh (3–750 μg/mL) induced relaxation, and the essential oil had a concentration-dependent vasorelaxant effect, without involvement of endothelial mediators.
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spelling pubmed-56031142017-09-26 Gas Chromatography-Triple Quadrupole Mass Spectrometry Analysis and Vasorelaxant Effect of Essential Oil from Protium heptaphyllum (Aubl.) March. Mobin, Mitra de Lima, Sidney G. Almeida, Lorena T. G. Silva Filho, José C. Rocha, Márcio S. Oliveira, Aldeídia P. Mendes, Marcelo B. Carvalho, Fernando A. A. Melhem, Marcia S. C. Costa, José G. M. Biomed Res Int Research Article The Protium heptaphyllum species, also known as Almécega, produces an oily resin, used in folk medicine as an analgesic and anti-inflammatory agent, in healing, and as an expectorant, which is rich in pentacyclic triterpenes and essential oils. In this study, the essential oil obtained by hydrodistillation of Almécega's resin was analyzed by gas chromatography-triple quadrupole mass spectrometry and evaluated for chemical composition and vasorelaxant activity in rat superior mesenteric artery. The main constituents determined by gas chromatography-triple quadrupole mass spectrometry were limonene, p-cineole, and o-cymene. In intact rings precontracted with phenylephrine (Phe 1 μM), EOPh (3–750 μg/mL) induced relaxation, and the essential oil had a concentration-dependent vasorelaxant effect, without involvement of endothelial mediators. Hindawi 2017 2017-08-30 /pmc/articles/PMC5603114/ /pubmed/28951867 http://dx.doi.org/10.1155/2017/1928171 Text en Copyright © 2017 Mitra Mobin et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mobin, Mitra
de Lima, Sidney G.
Almeida, Lorena T. G.
Silva Filho, José C.
Rocha, Márcio S.
Oliveira, Aldeídia P.
Mendes, Marcelo B.
Carvalho, Fernando A. A.
Melhem, Marcia S. C.
Costa, José G. M.
Gas Chromatography-Triple Quadrupole Mass Spectrometry Analysis and Vasorelaxant Effect of Essential Oil from Protium heptaphyllum (Aubl.) March.
title Gas Chromatography-Triple Quadrupole Mass Spectrometry Analysis and Vasorelaxant Effect of Essential Oil from Protium heptaphyllum (Aubl.) March.
title_full Gas Chromatography-Triple Quadrupole Mass Spectrometry Analysis and Vasorelaxant Effect of Essential Oil from Protium heptaphyllum (Aubl.) March.
title_fullStr Gas Chromatography-Triple Quadrupole Mass Spectrometry Analysis and Vasorelaxant Effect of Essential Oil from Protium heptaphyllum (Aubl.) March.
title_full_unstemmed Gas Chromatography-Triple Quadrupole Mass Spectrometry Analysis and Vasorelaxant Effect of Essential Oil from Protium heptaphyllum (Aubl.) March.
title_short Gas Chromatography-Triple Quadrupole Mass Spectrometry Analysis and Vasorelaxant Effect of Essential Oil from Protium heptaphyllum (Aubl.) March.
title_sort gas chromatography-triple quadrupole mass spectrometry analysis and vasorelaxant effect of essential oil from protium heptaphyllum (aubl.) march.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603114/
https://www.ncbi.nlm.nih.gov/pubmed/28951867
http://dx.doi.org/10.1155/2017/1928171
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