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Recombinant Vaccinia Viruses Coding Transgenes of Apoptosis-Inducing Proteins Enhance Apoptosis But Not Immunogenicity of Infected Tumor Cells

Genetic modifications of the oncolytic vaccinia virus (VV) improve selective tumor cell infection and death, as well as activation of antitumor immunity. We have engineered a double recombinant VV, coding human GM-CSF, and apoptosis-inducing protein apoptin (VV-GMCSF-Apo) for comparing with the earl...

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Detalles Bibliográficos
Autores principales:	Koval, Olga, Kochneva, Galina, Tkachenko, Anastasiya, Troitskaya, Olga, Sivolobova, Galina, Grazhdantseva, Antonina, Nushtaeva, Anna, Kuligina, Elena, Richter, Vladimir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603130/ https://www.ncbi.nlm.nih.gov/pubmed/28951871 http://dx.doi.org/10.1155/2017/3620510

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