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Human Long Noncoding RNA Regulation of Stem Cell Potency and Differentiation
Because of their capability of differentiation into lineage-specific cells, stem cells are an attractive therapeutic modality in regenerative medicine. To develop an effective stem cell-based therapeutic strategy with predictable results, deeper understanding of the underlying molecular mechanisms o...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603141/ https://www.ncbi.nlm.nih.gov/pubmed/28951743 http://dx.doi.org/10.1155/2017/6374504 |
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author | Lee, Seahyoung Seo, Hyang-Hee Lee, Chang Youn Lee, Jiyun Shin, Sunhye Kim, Sang Woo Lim, Soyeon Hwang, Ki-Chul |
author_facet | Lee, Seahyoung Seo, Hyang-Hee Lee, Chang Youn Lee, Jiyun Shin, Sunhye Kim, Sang Woo Lim, Soyeon Hwang, Ki-Chul |
author_sort | Lee, Seahyoung |
collection | PubMed |
description | Because of their capability of differentiation into lineage-specific cells, stem cells are an attractive therapeutic modality in regenerative medicine. To develop an effective stem cell-based therapeutic strategy with predictable results, deeper understanding of the underlying molecular mechanisms of stem cell differentiation and/or pluripotency maintenance is required. Thus, reviewing the key factors involved in the transcriptional and epigenetic regulation of stem cell differentiation and maintenance is important. Accumulating data indicate that long noncoding RNAs (lncRNAs) mediate numerous biological processes, including stem cell differentiation and maintenance. Here, we review recent findings on the human lncRNA regulation of stem cell potency and differentiation. Although the clinical implication of these lncRNAs is only beginning to be elucidated, it is anticipated that lncRNAs will become important therapeutic targets in the near future. |
format | Online Article Text |
id | pubmed-5603141 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-56031412017-09-26 Human Long Noncoding RNA Regulation of Stem Cell Potency and Differentiation Lee, Seahyoung Seo, Hyang-Hee Lee, Chang Youn Lee, Jiyun Shin, Sunhye Kim, Sang Woo Lim, Soyeon Hwang, Ki-Chul Stem Cells Int Review Article Because of their capability of differentiation into lineage-specific cells, stem cells are an attractive therapeutic modality in regenerative medicine. To develop an effective stem cell-based therapeutic strategy with predictable results, deeper understanding of the underlying molecular mechanisms of stem cell differentiation and/or pluripotency maintenance is required. Thus, reviewing the key factors involved in the transcriptional and epigenetic regulation of stem cell differentiation and maintenance is important. Accumulating data indicate that long noncoding RNAs (lncRNAs) mediate numerous biological processes, including stem cell differentiation and maintenance. Here, we review recent findings on the human lncRNA regulation of stem cell potency and differentiation. Although the clinical implication of these lncRNAs is only beginning to be elucidated, it is anticipated that lncRNAs will become important therapeutic targets in the near future. Hindawi 2017 2017-08-30 /pmc/articles/PMC5603141/ /pubmed/28951743 http://dx.doi.org/10.1155/2017/6374504 Text en Copyright © 2017 Seahyoung Lee et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Lee, Seahyoung Seo, Hyang-Hee Lee, Chang Youn Lee, Jiyun Shin, Sunhye Kim, Sang Woo Lim, Soyeon Hwang, Ki-Chul Human Long Noncoding RNA Regulation of Stem Cell Potency and Differentiation |
title | Human Long Noncoding RNA Regulation of Stem Cell Potency and Differentiation |
title_full | Human Long Noncoding RNA Regulation of Stem Cell Potency and Differentiation |
title_fullStr | Human Long Noncoding RNA Regulation of Stem Cell Potency and Differentiation |
title_full_unstemmed | Human Long Noncoding RNA Regulation of Stem Cell Potency and Differentiation |
title_short | Human Long Noncoding RNA Regulation of Stem Cell Potency and Differentiation |
title_sort | human long noncoding rna regulation of stem cell potency and differentiation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603141/ https://www.ncbi.nlm.nih.gov/pubmed/28951743 http://dx.doi.org/10.1155/2017/6374504 |
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