Binding of Factor VIII to Lipid Nanodiscs Increases its Clotting Function in a Mouse Model of Hemophilia A

BACKGROUND: Hemophilia A is a congenital bleeding disorder caused by defective or deficient factor VIII (FVIII). The active form of FVIII is the co-factor for the serine protease factor IXa (FIXa) in the membrane-bound intrinsic tenase (FVIIIa-FIXa) complex. The assembly of the FVIIIa-FIXa complex o...

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Detalles Bibliográficos
Autores principales: Csencsits-Smith, Keri, Grushin, Krill, Stoilova-McPhie, Svetla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603210/
https://www.ncbi.nlm.nih.gov/pubmed/28936365
http://dx.doi.org/10.4172/2155-9864.1000325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603210/
https://www.ncbi.nlm.nih.gov/pubmed/28936365
http://dx.doi.org/10.4172/2155-9864.1000325

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