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Ephrin-A2 regulates excitatory neuron differentiation and interneuron migration in the developing neocortex
The development of the neocortex requires co-ordination between proliferation and differentiation, as well as the precise orchestration of neuronal migration. Eph/ephrin signaling is crucial in guiding neurons and their projections during embryonic development. In adult ephrin-A2 knockout mice we co...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603509/ https://www.ncbi.nlm.nih.gov/pubmed/28924206 http://dx.doi.org/10.1038/s41598-017-12185-x |
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author | Homman-Ludiye, Jihane Kwan, William C. de Souza, Mitchell J. Rodger, Jennifer Bourne, James A. |
author_facet | Homman-Ludiye, Jihane Kwan, William C. de Souza, Mitchell J. Rodger, Jennifer Bourne, James A. |
author_sort | Homman-Ludiye, Jihane |
collection | PubMed |
description | The development of the neocortex requires co-ordination between proliferation and differentiation, as well as the precise orchestration of neuronal migration. Eph/ephrin signaling is crucial in guiding neurons and their projections during embryonic development. In adult ephrin-A2 knockout mice we consistently observed focal patches of disorganized neocortical laminar architecture, ranging in severity from reduced neuronal density to a complete lack of neurons. Loss of ephrin-A2 in the pre-optic area of the diencephalon reduced the migration of neocortex-bound interneurons from this region. Furthermore, ephrin-A2 participates in the creation of excitatory neurons by inhibiting apical progenitor proliferation in the ventricular zone, with the disruption of ephrin-A2 signaling in these cells recapitulating the abnormal neocortex observed in the knockout. The disturbance to the architecture of the neocortex observed following deletion of ephrin-A2 signaling shares many similarities with defects found in the neocortex of children diagnosed with autism spectrum disorder. |
format | Online Article Text |
id | pubmed-5603509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-56035092017-09-20 Ephrin-A2 regulates excitatory neuron differentiation and interneuron migration in the developing neocortex Homman-Ludiye, Jihane Kwan, William C. de Souza, Mitchell J. Rodger, Jennifer Bourne, James A. Sci Rep Article The development of the neocortex requires co-ordination between proliferation and differentiation, as well as the precise orchestration of neuronal migration. Eph/ephrin signaling is crucial in guiding neurons and their projections during embryonic development. In adult ephrin-A2 knockout mice we consistently observed focal patches of disorganized neocortical laminar architecture, ranging in severity from reduced neuronal density to a complete lack of neurons. Loss of ephrin-A2 in the pre-optic area of the diencephalon reduced the migration of neocortex-bound interneurons from this region. Furthermore, ephrin-A2 participates in the creation of excitatory neurons by inhibiting apical progenitor proliferation in the ventricular zone, with the disruption of ephrin-A2 signaling in these cells recapitulating the abnormal neocortex observed in the knockout. The disturbance to the architecture of the neocortex observed following deletion of ephrin-A2 signaling shares many similarities with defects found in the neocortex of children diagnosed with autism spectrum disorder. Nature Publishing Group UK 2017-09-18 /pmc/articles/PMC5603509/ /pubmed/28924206 http://dx.doi.org/10.1038/s41598-017-12185-x Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Homman-Ludiye, Jihane Kwan, William C. de Souza, Mitchell J. Rodger, Jennifer Bourne, James A. Ephrin-A2 regulates excitatory neuron differentiation and interneuron migration in the developing neocortex |
title | Ephrin-A2 regulates excitatory neuron differentiation and interneuron migration in the developing neocortex |
title_full | Ephrin-A2 regulates excitatory neuron differentiation and interneuron migration in the developing neocortex |
title_fullStr | Ephrin-A2 regulates excitatory neuron differentiation and interneuron migration in the developing neocortex |
title_full_unstemmed | Ephrin-A2 regulates excitatory neuron differentiation and interneuron migration in the developing neocortex |
title_short | Ephrin-A2 regulates excitatory neuron differentiation and interneuron migration in the developing neocortex |
title_sort | ephrin-a2 regulates excitatory neuron differentiation and interneuron migration in the developing neocortex |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603509/ https://www.ncbi.nlm.nih.gov/pubmed/28924206 http://dx.doi.org/10.1038/s41598-017-12185-x |
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