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Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration

Electrolyte concentration in sweat depends on environmental context and physical condition but also on the pathophysiological status. Sweat analyzers may be therefore the future way for biological survey although how sweat electrolyte composition can reflect plasma composition remains unclear. We re...

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Autores principales: Vairo, Donato, Bruzzese, Laurie, Marlinge, Marion, Fuster, Lea, Adjriou, Nabil, Kipson, Nathalie, Brunet, Philippe, Cautela, Jennifer, Jammes, Yves, Mottola, Giovanna, Burtey, Stephane, Ruf, Jean, Guieu, Regis, Fenouillet, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603548/
https://www.ncbi.nlm.nih.gov/pubmed/28924220
http://dx.doi.org/10.1038/s41598-017-12211-y
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author Vairo, Donato
Bruzzese, Laurie
Marlinge, Marion
Fuster, Lea
Adjriou, Nabil
Kipson, Nathalie
Brunet, Philippe
Cautela, Jennifer
Jammes, Yves
Mottola, Giovanna
Burtey, Stephane
Ruf, Jean
Guieu, Regis
Fenouillet, Emmanuel
author_facet Vairo, Donato
Bruzzese, Laurie
Marlinge, Marion
Fuster, Lea
Adjriou, Nabil
Kipson, Nathalie
Brunet, Philippe
Cautela, Jennifer
Jammes, Yves
Mottola, Giovanna
Burtey, Stephane
Ruf, Jean
Guieu, Regis
Fenouillet, Emmanuel
author_sort Vairo, Donato
collection PubMed
description Electrolyte concentration in sweat depends on environmental context and physical condition but also on the pathophysiological status. Sweat analyzers may be therefore the future way for biological survey although how sweat electrolyte composition can reflect plasma composition remains unclear. We recruited 10 healthy subjects and 6 patients to have a broad range of plasma electrolyte concentrations (chloride, potassium and sodium) and pH. These variables were compared to those found in sweat produced following cycling exercise or pilocarpine iontophoresis, a condition compatible with operating a wearable device. We found no correlation between plasma and sweat parameters when exercise-induced sweat was analyzed, and we could identify a correlation only between plasma and sweat potassium concentration (R = 0.78, p < 0.01) when sweat was induced using pilocarpine iontophoresis. We tested measurement repeatability in sweat at 24hr-interval for 3 days in 4 subjects and found a great intra-individual variability regarding all parameters in exercise-induced sweat whereas similar electrolyte levels were measured in pilocarpine-induced sweat. Thus, electrolyte concentration in sweat sampled following physical activity does not reflect concentration in plasma while pilocarpine iontophoresis appears to be promising to reproducibly address sweat electrolytes, and to make an indirect evaluation of plasma potassium concentration in chronic kidney disease and arrhythmia.
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spelling pubmed-56035482017-09-20 Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration Vairo, Donato Bruzzese, Laurie Marlinge, Marion Fuster, Lea Adjriou, Nabil Kipson, Nathalie Brunet, Philippe Cautela, Jennifer Jammes, Yves Mottola, Giovanna Burtey, Stephane Ruf, Jean Guieu, Regis Fenouillet, Emmanuel Sci Rep Article Electrolyte concentration in sweat depends on environmental context and physical condition but also on the pathophysiological status. Sweat analyzers may be therefore the future way for biological survey although how sweat electrolyte composition can reflect plasma composition remains unclear. We recruited 10 healthy subjects and 6 patients to have a broad range of plasma electrolyte concentrations (chloride, potassium and sodium) and pH. These variables were compared to those found in sweat produced following cycling exercise or pilocarpine iontophoresis, a condition compatible with operating a wearable device. We found no correlation between plasma and sweat parameters when exercise-induced sweat was analyzed, and we could identify a correlation only between plasma and sweat potassium concentration (R = 0.78, p < 0.01) when sweat was induced using pilocarpine iontophoresis. We tested measurement repeatability in sweat at 24hr-interval for 3 days in 4 subjects and found a great intra-individual variability regarding all parameters in exercise-induced sweat whereas similar electrolyte levels were measured in pilocarpine-induced sweat. Thus, electrolyte concentration in sweat sampled following physical activity does not reflect concentration in plasma while pilocarpine iontophoresis appears to be promising to reproducibly address sweat electrolytes, and to make an indirect evaluation of plasma potassium concentration in chronic kidney disease and arrhythmia. Nature Publishing Group UK 2017-09-18 /pmc/articles/PMC5603548/ /pubmed/28924220 http://dx.doi.org/10.1038/s41598-017-12211-y Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Vairo, Donato
Bruzzese, Laurie
Marlinge, Marion
Fuster, Lea
Adjriou, Nabil
Kipson, Nathalie
Brunet, Philippe
Cautela, Jennifer
Jammes, Yves
Mottola, Giovanna
Burtey, Stephane
Ruf, Jean
Guieu, Regis
Fenouillet, Emmanuel
Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration
title Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration
title_full Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration
title_fullStr Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration
title_full_unstemmed Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration
title_short Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration
title_sort towards addressing the body electrolyte environment via sweat analysis:pilocarpine iontophoresis supports assessment of plasma potassium concentration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603548/
https://www.ncbi.nlm.nih.gov/pubmed/28924220
http://dx.doi.org/10.1038/s41598-017-12211-y
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