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Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration
Electrolyte concentration in sweat depends on environmental context and physical condition but also on the pathophysiological status. Sweat analyzers may be therefore the future way for biological survey although how sweat electrolyte composition can reflect plasma composition remains unclear. We re...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603548/ https://www.ncbi.nlm.nih.gov/pubmed/28924220 http://dx.doi.org/10.1038/s41598-017-12211-y |
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author | Vairo, Donato Bruzzese, Laurie Marlinge, Marion Fuster, Lea Adjriou, Nabil Kipson, Nathalie Brunet, Philippe Cautela, Jennifer Jammes, Yves Mottola, Giovanna Burtey, Stephane Ruf, Jean Guieu, Regis Fenouillet, Emmanuel |
author_facet | Vairo, Donato Bruzzese, Laurie Marlinge, Marion Fuster, Lea Adjriou, Nabil Kipson, Nathalie Brunet, Philippe Cautela, Jennifer Jammes, Yves Mottola, Giovanna Burtey, Stephane Ruf, Jean Guieu, Regis Fenouillet, Emmanuel |
author_sort | Vairo, Donato |
collection | PubMed |
description | Electrolyte concentration in sweat depends on environmental context and physical condition but also on the pathophysiological status. Sweat analyzers may be therefore the future way for biological survey although how sweat electrolyte composition can reflect plasma composition remains unclear. We recruited 10 healthy subjects and 6 patients to have a broad range of plasma electrolyte concentrations (chloride, potassium and sodium) and pH. These variables were compared to those found in sweat produced following cycling exercise or pilocarpine iontophoresis, a condition compatible with operating a wearable device. We found no correlation between plasma and sweat parameters when exercise-induced sweat was analyzed, and we could identify a correlation only between plasma and sweat potassium concentration (R = 0.78, p < 0.01) when sweat was induced using pilocarpine iontophoresis. We tested measurement repeatability in sweat at 24hr-interval for 3 days in 4 subjects and found a great intra-individual variability regarding all parameters in exercise-induced sweat whereas similar electrolyte levels were measured in pilocarpine-induced sweat. Thus, electrolyte concentration in sweat sampled following physical activity does not reflect concentration in plasma while pilocarpine iontophoresis appears to be promising to reproducibly address sweat electrolytes, and to make an indirect evaluation of plasma potassium concentration in chronic kidney disease and arrhythmia. |
format | Online Article Text |
id | pubmed-5603548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-56035482017-09-20 Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration Vairo, Donato Bruzzese, Laurie Marlinge, Marion Fuster, Lea Adjriou, Nabil Kipson, Nathalie Brunet, Philippe Cautela, Jennifer Jammes, Yves Mottola, Giovanna Burtey, Stephane Ruf, Jean Guieu, Regis Fenouillet, Emmanuel Sci Rep Article Electrolyte concentration in sweat depends on environmental context and physical condition but also on the pathophysiological status. Sweat analyzers may be therefore the future way for biological survey although how sweat electrolyte composition can reflect plasma composition remains unclear. We recruited 10 healthy subjects and 6 patients to have a broad range of plasma electrolyte concentrations (chloride, potassium and sodium) and pH. These variables were compared to those found in sweat produced following cycling exercise or pilocarpine iontophoresis, a condition compatible with operating a wearable device. We found no correlation between plasma and sweat parameters when exercise-induced sweat was analyzed, and we could identify a correlation only between plasma and sweat potassium concentration (R = 0.78, p < 0.01) when sweat was induced using pilocarpine iontophoresis. We tested measurement repeatability in sweat at 24hr-interval for 3 days in 4 subjects and found a great intra-individual variability regarding all parameters in exercise-induced sweat whereas similar electrolyte levels were measured in pilocarpine-induced sweat. Thus, electrolyte concentration in sweat sampled following physical activity does not reflect concentration in plasma while pilocarpine iontophoresis appears to be promising to reproducibly address sweat electrolytes, and to make an indirect evaluation of plasma potassium concentration in chronic kidney disease and arrhythmia. Nature Publishing Group UK 2017-09-18 /pmc/articles/PMC5603548/ /pubmed/28924220 http://dx.doi.org/10.1038/s41598-017-12211-y Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Vairo, Donato Bruzzese, Laurie Marlinge, Marion Fuster, Lea Adjriou, Nabil Kipson, Nathalie Brunet, Philippe Cautela, Jennifer Jammes, Yves Mottola, Giovanna Burtey, Stephane Ruf, Jean Guieu, Regis Fenouillet, Emmanuel Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration |
title | Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration |
title_full | Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration |
title_fullStr | Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration |
title_full_unstemmed | Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration |
title_short | Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration |
title_sort | towards addressing the body electrolyte environment via sweat analysis:pilocarpine iontophoresis supports assessment of plasma potassium concentration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603548/ https://www.ncbi.nlm.nih.gov/pubmed/28924220 http://dx.doi.org/10.1038/s41598-017-12211-y |
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