Infection of microglia with Porphyromonas gingivalis promotes cell migration and an inflammatory response through the gingipain-mediated activation of protease-activated receptor-2 in mice

Despite a clear correlation between periodontitis and cognitive decline in Alzheimer’s disease, the precise mechanism underlying the relationship remains unclear. The periodontal pathogen Porphyromonas gingivalis produces a unique class of cysteine proteinases termed gingipains that comprises Arg-gi...

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Detalles Bibliográficos
Autores principales: Liu, Yicong, Wu, Zhou, Nakanishi, Yurika, Ni, Junjun, Hayashi, Yoshinori, Takayama, Fumiko, Zhou, Yanmin, Kadowaki, Tomoko, Nakanishi, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603557/
https://www.ncbi.nlm.nih.gov/pubmed/28924232
http://dx.doi.org/10.1038/s41598-017-12173-1

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