NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer’s, and Ethanol Intoxication

Glutamate carboxypeptidase II (GCPII) inactivates the peptide neurotransmitter N-acetylaspartylglutamate (NAAG) following synaptic release. Inhibitors of GCPII increase extracellular NAAG levels and are efficacious in animal models of clinical disorders via NAAG activation of a group II metabotropic...

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Detalles Bibliográficos
Autores principales: Olszewski, Rafal T., Janczura, Karolina J., Bzdega, Tomasz, Der, Elise K., Venzor, Faustino, O’Rourke, Brennen, Hark, Timothy J., Craddock, Kirsten E., Balasubramanian, Shankar, Moussa, Charbel, Neale, Joseph H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603630/
https://www.ncbi.nlm.nih.gov/pubmed/28285415
http://dx.doi.org/10.1007/s11064-017-2181-4

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