Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides

A palladium-catalyzed difluoromethylation of a series of heteroaryl chlorides, bromides and iodides under mild conditions is described. A wide range of heteroaryl halides such as pyridyl, pyrimidyl, pyrazyl, funanyl, thienyl, pyazolyl, imidazolyl, thiazolyl, and oxazolyl halides were efficiently dif...

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Detalles Bibliográficos
Autores principales: Lu, Changhui, Gu, Yang, Wu, Jiang, Gu, Yucheng, Shen, Qilong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603793/
https://www.ncbi.nlm.nih.gov/pubmed/28959407
http://dx.doi.org/10.1039/c7sc00691h
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author Lu, Changhui
Gu, Yang
Wu, Jiang
Gu, Yucheng
Shen, Qilong
author_facet Lu, Changhui
Gu, Yang
Wu, Jiang
Gu, Yucheng
Shen, Qilong
author_sort Lu, Changhui
collection PubMed
description A palladium-catalyzed difluoromethylation of a series of heteroaryl chlorides, bromides and iodides under mild conditions is described. A wide range of heteroaryl halides such as pyridyl, pyrimidyl, pyrazyl, funanyl, thienyl, pyazolyl, imidazolyl, thiazolyl, and oxazolyl halides were efficiently difluoromethylated, thus providing medicinal chemists an alternative choice for the preparation of drug candidates with the difluoromethylated heteroarene unit.
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spelling pubmed-56037932017-09-28 Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides Lu, Changhui Gu, Yang Wu, Jiang Gu, Yucheng Shen, Qilong Chem Sci Chemistry A palladium-catalyzed difluoromethylation of a series of heteroaryl chlorides, bromides and iodides under mild conditions is described. A wide range of heteroaryl halides such as pyridyl, pyrimidyl, pyrazyl, funanyl, thienyl, pyazolyl, imidazolyl, thiazolyl, and oxazolyl halides were efficiently difluoromethylated, thus providing medicinal chemists an alternative choice for the preparation of drug candidates with the difluoromethylated heteroarene unit. Royal Society of Chemistry 2017-07-01 2017-04-24 /pmc/articles/PMC5603793/ /pubmed/28959407 http://dx.doi.org/10.1039/c7sc00691h Text en This journal is © The Royal Society of Chemistry 2017 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Lu, Changhui
Gu, Yang
Wu, Jiang
Gu, Yucheng
Shen, Qilong
Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides
title Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides
title_full Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides
title_fullStr Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides
title_full_unstemmed Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides
title_short Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides
title_sort palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603793/
https://www.ncbi.nlm.nih.gov/pubmed/28959407
http://dx.doi.org/10.1039/c7sc00691h
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AT guyucheng palladiumcatalyzeddifluoromethylationofheteroarylchloridesbromidesandiodides
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