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Teratogenic Effects of Intravitreal Injection of Bevacizumab in a Pregnant Rat Model
In this research study, to investigate teratogenic effect of intravitreal injection of bevacizumab in pregnant rat model, twenty seven female Wistar rats were inseminated. Pregnant rats were divided into 6 groups (three groups as case and three as control groups). Each case and control groups were d...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603876/ https://www.ncbi.nlm.nih.gov/pubmed/28979321 |
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author | Bamdad, Shahram Bamdad, Mina Khanlari, Mahsa Daneshbod, Yahya Khademi, Behzad |
author_facet | Bamdad, Shahram Bamdad, Mina Khanlari, Mahsa Daneshbod, Yahya Khademi, Behzad |
author_sort | Bamdad, Shahram |
collection | PubMed |
description | In this research study, to investigate teratogenic effect of intravitreal injection of bevacizumab in pregnant rat model, twenty seven female Wistar rats were inseminated. Pregnant rats were divided into 6 groups (three groups as case and three as control groups). Each case and control groups were divided according to the day of intravitreal injections (day 2, 10 and 18). Rats in the case groups received 4 µL intravitreal injection of bevacizumab and the control groups received the same volume of distilled water. The tail and umbilical cord length in case groups 1, 2, and 3 did not display any significant differences compared to their control groups. The fetal weight was significantly lower in the case groups 1 (p>0.001) and 2 (p>0.001) compared to their control groups. Furthermore, the placental weight was only lower in the case group 1 (p>0.001). Case group 2 had a shorter crown rump length in comparison with its control group (p=0.029). Morphological investigations showed two abnormal cases of gastroschisis in group 1 and a case of a cleft in the skull in one of the rats in case group 2. The results show that intravitreal bevacizumab has developmental effect when administered in the early stages of pregnancy; but it is safe when administered in the last week of pregnancy in rats. |
format | Online Article Text |
id | pubmed-5603876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-56038762017-10-04 Teratogenic Effects of Intravitreal Injection of Bevacizumab in a Pregnant Rat Model Bamdad, Shahram Bamdad, Mina Khanlari, Mahsa Daneshbod, Yahya Khademi, Behzad Iran J Pharm Res Original Article In this research study, to investigate teratogenic effect of intravitreal injection of bevacizumab in pregnant rat model, twenty seven female Wistar rats were inseminated. Pregnant rats were divided into 6 groups (three groups as case and three as control groups). Each case and control groups were divided according to the day of intravitreal injections (day 2, 10 and 18). Rats in the case groups received 4 µL intravitreal injection of bevacizumab and the control groups received the same volume of distilled water. The tail and umbilical cord length in case groups 1, 2, and 3 did not display any significant differences compared to their control groups. The fetal weight was significantly lower in the case groups 1 (p>0.001) and 2 (p>0.001) compared to their control groups. Furthermore, the placental weight was only lower in the case group 1 (p>0.001). Case group 2 had a shorter crown rump length in comparison with its control group (p=0.029). Morphological investigations showed two abnormal cases of gastroschisis in group 1 and a case of a cleft in the skull in one of the rats in case group 2. The results show that intravitreal bevacizumab has developmental effect when administered in the early stages of pregnancy; but it is safe when administered in the last week of pregnancy in rats. Shaheed Beheshti University of Medical Sciences 2017 /pmc/articles/PMC5603876/ /pubmed/28979321 Text en © 2017 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Bamdad, Shahram Bamdad, Mina Khanlari, Mahsa Daneshbod, Yahya Khademi, Behzad Teratogenic Effects of Intravitreal Injection of Bevacizumab in a Pregnant Rat Model |
title | Teratogenic Effects of Intravitreal Injection of Bevacizumab in a Pregnant Rat Model |
title_full | Teratogenic Effects of Intravitreal Injection of Bevacizumab in a Pregnant Rat Model |
title_fullStr | Teratogenic Effects of Intravitreal Injection of Bevacizumab in a Pregnant Rat Model |
title_full_unstemmed | Teratogenic Effects of Intravitreal Injection of Bevacizumab in a Pregnant Rat Model |
title_short | Teratogenic Effects of Intravitreal Injection of Bevacizumab in a Pregnant Rat Model |
title_sort | teratogenic effects of intravitreal injection of bevacizumab in a pregnant rat model |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603876/ https://www.ncbi.nlm.nih.gov/pubmed/28979321 |
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