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Structure–Activity Relationships Reveal Key Features of 8-Oxoguanine: A Mismatch Detection by the MutY Glycosylase

[Image: see text] Base excision repair glycosylases locate and remove damaged bases in DNA with remarkable specificity. The MutY glycosylases, unusual for their excision of undamaged adenines mispaired to the oxidized base 8-oxoguanine (OG), must recognize both bases of the mispair in order to preve...

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Detalles Bibliográficos
Autores principales:	Manlove, Amelia H., McKibbin, Paige L., Doyle, Emily L., Majumdar, Chandrima, Hamm, Michelle L., David, Sheila S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603899/ https://www.ncbi.nlm.nih.gov/pubmed/28723094 http://dx.doi.org/10.1021/acschembio.7b00389

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