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Inhibition of the Ras/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(iii) metal-based compound

Targeting protein–protein interactions (PPIs) offers tantalizing opportunities for therapeutic intervention for the treatment of human diseases. Modulating PPI interfaces with organic small molecules has been found to be exceptionally challenging, and few candidates have been successfully developed...

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Detalles Bibliográficos
Autores principales:	Liu, Li-Juan, Wang, Wanhe, Huang, Shi-Ying, Hong, Yanjun, Li, Guodong, Lin, Sheng, Tian, Jinglin, Cai, Zongwei, Wang, Hui-Min David, Ma, Dik-Lung, Leung, Chung-Hang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2017
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603957/ https://www.ncbi.nlm.nih.gov/pubmed/28959398 http://dx.doi.org/10.1039/c7sc00311k

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