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The Potential and Challenges of Exploiting the Vast But Dynamic Neoepitope Landscape for Immunotherapy
Somatic non-synonymous mutations in the DNA of tumor cells may result in the presentation of tumor-specific peptides to T cells. The recognition of these so-called neoepitopes now has been firmly linked to the clinical success of checkpoint blockade and adoptive T cell therapy. Following proof-of-pr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604073/ https://www.ncbi.nlm.nih.gov/pubmed/28959257 http://dx.doi.org/10.3389/fimmu.2017.01113 |