Acute Liver Failure Due to Echovirus 9 Associated With Persistent B-Cell Depletion From Rituximab

We describe a case of fatal acute liver failure due to echovirus 9 in the setting of persistent B-cell depletion and hypogammaglobulinemia 3 years after rituximab therapy. Metagenomic next-generation sequencing further specified the etiologic agent. Early recognition may provide an opportunity for i...

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Detalles Bibliográficos
Autores principales: Bajema, Kristina L, Simonson, Paul D, Greninger, Alex L, Çoruh, Basak, Pottinger, Paul S, Bhattacharya, Renuka, Liou, Iris W, Jalikis, Florencia G, Fligner, Corinne L, Rakita, Robert M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604094/
https://www.ncbi.nlm.nih.gov/pubmed/28948184
http://dx.doi.org/10.1093/ofid/ofx174
Descripción
Sumario:We describe a case of fatal acute liver failure due to echovirus 9 in the setting of persistent B-cell depletion and hypogammaglobulinemia 3 years after rituximab therapy. Metagenomic next-generation sequencing further specified the etiologic agent. Early recognition may provide an opportunity for interventions including intravenous immunoglobulin and liver transplantation.

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