Acute Liver Failure Due to Echovirus 9 Associated With Persistent B-Cell Depletion From Rituximab

We describe a case of fatal acute liver failure due to echovirus 9 in the setting of persistent B-cell depletion and hypogammaglobulinemia 3 years after rituximab therapy. Metagenomic next-generation sequencing further specified the etiologic agent. Early recognition may provide an opportunity for i...

Descripción completa

Detalles Bibliográficos
Autores principales: Bajema, Kristina L, Simonson, Paul D, Greninger, Alex L, Çoruh, Basak, Pottinger, Paul S, Bhattacharya, Renuka, Liou, Iris W, Jalikis, Florencia G, Fligner, Corinne L, Rakita, Robert M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604094/
https://www.ncbi.nlm.nih.gov/pubmed/28948184
http://dx.doi.org/10.1093/ofid/ofx174
_version_ 1783264807747584000
author Bajema, Kristina L
Simonson, Paul D
Greninger, Alex L
Çoruh, Basak
Pottinger, Paul S
Bhattacharya, Renuka
Liou, Iris W
Jalikis, Florencia G
Fligner, Corinne L
Rakita, Robert M
author_facet Bajema, Kristina L
Simonson, Paul D
Greninger, Alex L
Çoruh, Basak
Pottinger, Paul S
Bhattacharya, Renuka
Liou, Iris W
Jalikis, Florencia G
Fligner, Corinne L
Rakita, Robert M
author_sort Bajema, Kristina L
collection PubMed
description We describe a case of fatal acute liver failure due to echovirus 9 in the setting of persistent B-cell depletion and hypogammaglobulinemia 3 years after rituximab therapy. Metagenomic next-generation sequencing further specified the etiologic agent. Early recognition may provide an opportunity for interventions including intravenous immunoglobulin and liver transplantation.
format Online
Article
Text
id pubmed-5604094
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-56040942017-09-25 Acute Liver Failure Due to Echovirus 9 Associated With Persistent B-Cell Depletion From Rituximab Bajema, Kristina L Simonson, Paul D Greninger, Alex L Çoruh, Basak Pottinger, Paul S Bhattacharya, Renuka Liou, Iris W Jalikis, Florencia G Fligner, Corinne L Rakita, Robert M Open Forum Infect Dis Brief Report We describe a case of fatal acute liver failure due to echovirus 9 in the setting of persistent B-cell depletion and hypogammaglobulinemia 3 years after rituximab therapy. Metagenomic next-generation sequencing further specified the etiologic agent. Early recognition may provide an opportunity for interventions including intravenous immunoglobulin and liver transplantation. Oxford University Press 2017-08-14 /pmc/articles/PMC5604094/ /pubmed/28948184 http://dx.doi.org/10.1093/ofid/ofx174 Text en © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Bajema, Kristina L
Simonson, Paul D
Greninger, Alex L
Çoruh, Basak
Pottinger, Paul S
Bhattacharya, Renuka
Liou, Iris W
Jalikis, Florencia G
Fligner, Corinne L
Rakita, Robert M
Acute Liver Failure Due to Echovirus 9 Associated With Persistent B-Cell Depletion From Rituximab
title Acute Liver Failure Due to Echovirus 9 Associated With Persistent B-Cell Depletion From Rituximab
title_full Acute Liver Failure Due to Echovirus 9 Associated With Persistent B-Cell Depletion From Rituximab
title_fullStr Acute Liver Failure Due to Echovirus 9 Associated With Persistent B-Cell Depletion From Rituximab
title_full_unstemmed Acute Liver Failure Due to Echovirus 9 Associated With Persistent B-Cell Depletion From Rituximab
title_short Acute Liver Failure Due to Echovirus 9 Associated With Persistent B-Cell Depletion From Rituximab
title_sort acute liver failure due to echovirus 9 associated with persistent b-cell depletion from rituximab
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604094/
https://www.ncbi.nlm.nih.gov/pubmed/28948184
http://dx.doi.org/10.1093/ofid/ofx174
work_keys_str_mv AT bajemakristinal acuteliverfailureduetoechovirus9associatedwithpersistentbcelldepletionfromrituximab
AT simonsonpauld acuteliverfailureduetoechovirus9associatedwithpersistentbcelldepletionfromrituximab
AT greningeralexl acuteliverfailureduetoechovirus9associatedwithpersistentbcelldepletionfromrituximab
AT coruhbasak acuteliverfailureduetoechovirus9associatedwithpersistentbcelldepletionfromrituximab
AT pottingerpauls acuteliverfailureduetoechovirus9associatedwithpersistentbcelldepletionfromrituximab
AT bhattacharyarenuka acuteliverfailureduetoechovirus9associatedwithpersistentbcelldepletionfromrituximab
AT liouirisw acuteliverfailureduetoechovirus9associatedwithpersistentbcelldepletionfromrituximab
AT jalikisflorenciag acuteliverfailureduetoechovirus9associatedwithpersistentbcelldepletionfromrituximab
AT flignercorinnel acuteliverfailureduetoechovirus9associatedwithpersistentbcelldepletionfromrituximab
AT rakitarobertm acuteliverfailureduetoechovirus9associatedwithpersistentbcelldepletionfromrituximab

Ejemplares similares