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Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a literature review
Interstitial lung disease (ILD) is a major pulmonary manifestation of connective tissue disease (CTD), leading to significant morbidity and mortality. Chest high-resolution computed tomography (HRCT) is presently considered the diagnostic gold standard for pulmonary fibrosis diagnosis and quantifica...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604136/ https://www.ncbi.nlm.nih.gov/pubmed/28923086 http://dx.doi.org/10.1186/s13075-017-1409-7 |
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author | Wang, YuKai Gargani, Luna Barskova, Tatiana Furst, Dan E. Cerinic, Marco Matucci |
author_facet | Wang, YuKai Gargani, Luna Barskova, Tatiana Furst, Dan E. Cerinic, Marco Matucci |
author_sort | Wang, YuKai |
collection | PubMed |
description | Interstitial lung disease (ILD) is a major pulmonary manifestation of connective tissue disease (CTD), leading to significant morbidity and mortality. Chest high-resolution computed tomography (HRCT) is presently considered the diagnostic gold standard for pulmonary fibrosis diagnosis and quantification in the clinical arena. However, not negligible doses of ionizing radiation limit the use of HRCT, especially for serial follow-up in younger female patients. In the past decade, lung ultrasound (LUS) has been proposed to assess ILD by detecting and quantifying sonographic B-lines. Previous studies demonstrate that B-lines have a good diagnostic accuracy, especially high sensitivity, and correlate well with HRCT findings, suggesting LUS as a novel, non-invasive, and non-ionizing imaging method to be used in patients with CTD-ILD. Although preliminary data are promising, challenges and controversies still remain. For example, the mechanisms of B-line generation are not fully understood; the diagnostic accuracy and performance characteristics of LUS partially depend on the scanning scheme and scoring system used; and up-to-date B-lines cannot discriminate the early cellular inflammation from the chronic fibrotic phase in CTD-ILD. Therefore it is important for clinicians to understand the strengths and limitations of LUS in CTD-ILD patients, to maximize its value. |
format | Online Article Text |
id | pubmed-5604136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-56041362017-09-21 Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a literature review Wang, YuKai Gargani, Luna Barskova, Tatiana Furst, Dan E. Cerinic, Marco Matucci Arthritis Res Ther Review Interstitial lung disease (ILD) is a major pulmonary manifestation of connective tissue disease (CTD), leading to significant morbidity and mortality. Chest high-resolution computed tomography (HRCT) is presently considered the diagnostic gold standard for pulmonary fibrosis diagnosis and quantification in the clinical arena. However, not negligible doses of ionizing radiation limit the use of HRCT, especially for serial follow-up in younger female patients. In the past decade, lung ultrasound (LUS) has been proposed to assess ILD by detecting and quantifying sonographic B-lines. Previous studies demonstrate that B-lines have a good diagnostic accuracy, especially high sensitivity, and correlate well with HRCT findings, suggesting LUS as a novel, non-invasive, and non-ionizing imaging method to be used in patients with CTD-ILD. Although preliminary data are promising, challenges and controversies still remain. For example, the mechanisms of B-line generation are not fully understood; the diagnostic accuracy and performance characteristics of LUS partially depend on the scanning scheme and scoring system used; and up-to-date B-lines cannot discriminate the early cellular inflammation from the chronic fibrotic phase in CTD-ILD. Therefore it is important for clinicians to understand the strengths and limitations of LUS in CTD-ILD patients, to maximize its value. BioMed Central 2017-09-18 2017 /pmc/articles/PMC5604136/ /pubmed/28923086 http://dx.doi.org/10.1186/s13075-017-1409-7 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Wang, YuKai Gargani, Luna Barskova, Tatiana Furst, Dan E. Cerinic, Marco Matucci Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a literature review |
title | Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a literature review |
title_full | Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a literature review |
title_fullStr | Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a literature review |
title_full_unstemmed | Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a literature review |
title_short | Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a literature review |
title_sort | usefulness of lung ultrasound b-lines in connective tissue disease-associated interstitial lung disease: a literature review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604136/ https://www.ncbi.nlm.nih.gov/pubmed/28923086 http://dx.doi.org/10.1186/s13075-017-1409-7 |
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