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Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future

In today’s clinical practice patients’ skin is used as screening organ for diagnosing type 1 allergy. According to European guidelines skin prick testing with a panel of 18 allergen extracts is recommended, in the US between 10 to 50 allergens are used. The specificity and sensitivity of skin testin...

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Autores principales: Jensen-Jarolim, E., Jensen, A. N., Canonica, G. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604284/
https://www.ncbi.nlm.nih.gov/pubmed/28959378
http://dx.doi.org/10.1186/s40413-017-0162-3
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author Jensen-Jarolim, E.
Jensen, A. N.
Canonica, G. W.
author_facet Jensen-Jarolim, E.
Jensen, A. N.
Canonica, G. W.
author_sort Jensen-Jarolim, E.
collection PubMed
description In today’s clinical practice patients’ skin is used as screening organ for diagnosing type 1 allergy. According to European guidelines skin prick testing with a panel of 18 allergen extracts is recommended, in the US between 10 to 50 allergens are used. The specificity and sensitivity of skin testing is individually highly variable depending on age, body mass, and skin barrier status. In atopic inflammation skin testing gives more false positive results. Smaller skin area and strain limits prick testing in small children. Although the risk for systemic reactions in skin prick testing is very small, emergency medications must be available. Considering the fact that IgE is the only reliable biomarker for type I allergy, upfront IgE screening with ISAC, followed by fewer skin tests to approve positive sensitizations, is proposed. It is time to arrive in the age of molecular allergy diagnosis in daily patient care.
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spelling pubmed-56042842017-09-28 Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future Jensen-Jarolim, E. Jensen, A. N. Canonica, G. W. World Allergy Organ J Debate In today’s clinical practice patients’ skin is used as screening organ for diagnosing type 1 allergy. According to European guidelines skin prick testing with a panel of 18 allergen extracts is recommended, in the US between 10 to 50 allergens are used. The specificity and sensitivity of skin testing is individually highly variable depending on age, body mass, and skin barrier status. In atopic inflammation skin testing gives more false positive results. Smaller skin area and strain limits prick testing in small children. Although the risk for systemic reactions in skin prick testing is very small, emergency medications must be available. Considering the fact that IgE is the only reliable biomarker for type I allergy, upfront IgE screening with ISAC, followed by fewer skin tests to approve positive sensitizations, is proposed. It is time to arrive in the age of molecular allergy diagnosis in daily patient care. BioMed Central 2017-09-19 /pmc/articles/PMC5604284/ /pubmed/28959378 http://dx.doi.org/10.1186/s40413-017-0162-3 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Debate
Jensen-Jarolim, E.
Jensen, A. N.
Canonica, G. W.
Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future
title Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future
title_full Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future
title_fullStr Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future
title_full_unstemmed Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future
title_short Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future
title_sort debates in allergy medicine: molecular allergy diagnosis with isac will replace screenings by skin prick test in the future
topic Debate
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604284/
https://www.ncbi.nlm.nih.gov/pubmed/28959378
http://dx.doi.org/10.1186/s40413-017-0162-3
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