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Sero-epidemiology study of leptospirosis in febrile patients from Terai region of Nepal

BACKGROUND: Leptospirosis is a re-emerging zoonotic disease caused by pathogenic strains of bacteria belonging to genus Leptospira whose symptoms can range from mild clinical manifestations to a severe life threatening illness. This disease may be under-recognized in resource poor settings like Nepa...

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Autores principales: Regmi, Lalmani, Pandey, Kishor, Malla, Meena, Khanal, Santosh, Pandey, Basu Dev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604353/
https://www.ncbi.nlm.nih.gov/pubmed/28923024
http://dx.doi.org/10.1186/s12879-017-2733-x
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author Regmi, Lalmani
Pandey, Kishor
Malla, Meena
Khanal, Santosh
Pandey, Basu Dev
author_facet Regmi, Lalmani
Pandey, Kishor
Malla, Meena
Khanal, Santosh
Pandey, Basu Dev
author_sort Regmi, Lalmani
collection PubMed
description BACKGROUND: Leptospirosis is a re-emerging zoonotic disease caused by pathogenic strains of bacteria belonging to genus Leptospira whose symptoms can range from mild clinical manifestations to a severe life threatening illness. This disease may be under-recognized in resource poor settings like Nepal where many clinical laboratories lack appropriate equipment, technology and personnel for proper diagnosis. METHODS: We used IgM ELISA to estimate the sero-prevalence of leptospirosis in a group of febrile patients in a western region of Nepal. We also tested for possible co-infection with two other common febrile diseases endemic to Nepal including dengue and typhoid fever. RESULTS: Among samples from 144 febrile patients, 30 (21%) were positive for leptospiral IgM. In univariate analysis, leptospirosis was significantly associated with being of working age (p = 0.019), farming (p = 0.045) and water and animal contact (p = 0.0001). Widal and dengue serological study showed that the majority of leptospirosis infections did not have an alternative diagnosis. CONCLUSION: As indicated by the study, regular surveillance of animal reservoirs in collaboration with veterinary department and inclusion of leptospirosis as a differential diagnosis of febrile illness is thus recommended based on the current findings.
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spelling pubmed-56043532017-09-21 Sero-epidemiology study of leptospirosis in febrile patients from Terai region of Nepal Regmi, Lalmani Pandey, Kishor Malla, Meena Khanal, Santosh Pandey, Basu Dev BMC Infect Dis Research Article BACKGROUND: Leptospirosis is a re-emerging zoonotic disease caused by pathogenic strains of bacteria belonging to genus Leptospira whose symptoms can range from mild clinical manifestations to a severe life threatening illness. This disease may be under-recognized in resource poor settings like Nepal where many clinical laboratories lack appropriate equipment, technology and personnel for proper diagnosis. METHODS: We used IgM ELISA to estimate the sero-prevalence of leptospirosis in a group of febrile patients in a western region of Nepal. We also tested for possible co-infection with two other common febrile diseases endemic to Nepal including dengue and typhoid fever. RESULTS: Among samples from 144 febrile patients, 30 (21%) were positive for leptospiral IgM. In univariate analysis, leptospirosis was significantly associated with being of working age (p = 0.019), farming (p = 0.045) and water and animal contact (p = 0.0001). Widal and dengue serological study showed that the majority of leptospirosis infections did not have an alternative diagnosis. CONCLUSION: As indicated by the study, regular surveillance of animal reservoirs in collaboration with veterinary department and inclusion of leptospirosis as a differential diagnosis of febrile illness is thus recommended based on the current findings. BioMed Central 2017-09-18 /pmc/articles/PMC5604353/ /pubmed/28923024 http://dx.doi.org/10.1186/s12879-017-2733-x Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Regmi, Lalmani
Pandey, Kishor
Malla, Meena
Khanal, Santosh
Pandey, Basu Dev
Sero-epidemiology study of leptospirosis in febrile patients from Terai region of Nepal
title Sero-epidemiology study of leptospirosis in febrile patients from Terai region of Nepal
title_full Sero-epidemiology study of leptospirosis in febrile patients from Terai region of Nepal
title_fullStr Sero-epidemiology study of leptospirosis in febrile patients from Terai region of Nepal
title_full_unstemmed Sero-epidemiology study of leptospirosis in febrile patients from Terai region of Nepal
title_short Sero-epidemiology study of leptospirosis in febrile patients from Terai region of Nepal
title_sort sero-epidemiology study of leptospirosis in febrile patients from terai region of nepal
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604353/
https://www.ncbi.nlm.nih.gov/pubmed/28923024
http://dx.doi.org/10.1186/s12879-017-2733-x
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