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Roflumilast reverses CFTR-mediated ion transport dysfunction in cigarette smoke-exposed mice

BACKGROUND: Dysfunction in cystic fibrosis transmembrane conductance regulator (CFTR) can be elicited by cigarette smoke and is observed in patients with chronic bronchitis. We have previously demonstrated in human airway epithelial cell monolayers that roflumilast, a clinically approved phosphodies...

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Detalles Bibliográficos
Autores principales:	Raju, S. Vamsee, Rasmussen, Lawrence, Sloane, Peter A., Tang, Li Ping, Libby, Emily Falk, Rowe, Steven M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604356/ https://www.ncbi.nlm.nih.gov/pubmed/28923049 http://dx.doi.org/10.1186/s12931-017-0656-0

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