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Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss

BACKGROUND: Pharmacologic inhibition of C5aR1, a receptor for the complement activation proinflammatory fragment, C5a, suppressed pathology and cognitive deficits in Alzheimer's disease (AD) mouse models. To validate that the effect of the antagonist was specifically via C5aR1 inhibition, mice...

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Detalles Bibliográficos
Autores principales:	Hernandez, Michael X., Jiang, Shan, Cole, Tracy A., Chu, Shu-Hui, Fonseca, Maria I., Fang, Melody J., Hohsfield, Lindsay A., Torres, Maria D., Green, Kim N., Wetsel, Rick A., Mortazavi, Ali, Tenner, Andrea J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604420/ https://www.ncbi.nlm.nih.gov/pubmed/28923083 http://dx.doi.org/10.1186/s13024-017-0210-z

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