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High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway

BACKGROUND: Mechanical overloading can lead to disc degeneration. Nucleus pulposus (NP) cell senescence is aggravated within the degenerated disc. This study was designed to investigate the effects of high compression on NP cell senescence and the underlying molecular mechanism of this process. METH...

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Detalles Bibliográficos
Autores principales:	Li, Pei, Hou, Gang, Zhang, Ruijie, Gan, Yibo, Xu, Yuan, Song, Lei, Zhou, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604423/ https://www.ncbi.nlm.nih.gov/pubmed/28923094 http://dx.doi.org/10.1186/s13075-017-1384-z

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