8-Oxo-7,8-dihydroguanine in the Context of a Gene Promoter G-Quadruplex Is an On–Off Switch for Transcription

[Image: see text] Interplay between DNA repair of the oxidatively modified base 8-oxo-7,8-dihydroguanine (OG) and transcriptional activation has been documented in mammalian genes. Previously, we synthesized OG into the VEGF potential G-quadruplex sequence (PQS) in the coding strand of a luciferase...

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Detalles Bibliográficos
Autores principales: Fleming, Aaron M., Zhu, Judy, Ding, Yun, Burrows, Cynthia J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604463/
https://www.ncbi.nlm.nih.gov/pubmed/28829124
http://dx.doi.org/10.1021/acschembio.7b00636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604463/
https://www.ncbi.nlm.nih.gov/pubmed/28829124
http://dx.doi.org/10.1021/acschembio.7b00636

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