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8-Oxo-7,8-dihydroguanine in the Context of a Gene Promoter G-Quadruplex Is an On–Off Switch for Transcription

[Image: see text] Interplay between DNA repair of the oxidatively modified base 8-oxo-7,8-dihydroguanine (OG) and transcriptional activation has been documented in mammalian genes. Previously, we synthesized OG into the VEGF potential G-quadruplex sequence (PQS) in the coding strand of a luciferase...

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Detalles Bibliográficos
Autores principales:	Fleming, Aaron M., Zhu, Judy, Ding, Yun, Burrows, Cynthia J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604463/ https://www.ncbi.nlm.nih.gov/pubmed/28829124 http://dx.doi.org/10.1021/acschembio.7b00636

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