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Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma

BACKGROUND: This study aimed to identify the clinical and pathological characteristics and the possible prognostic factors for Chinese patients with early-stage ovarian endometrioid carcinoma. METHODS: The present study reviewed the medical records of patients who received initial treatment and a po...

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Autores principales: Zhao, Yu, Wang, Shu, Qu, Yi-Min, Ji, Yu-Ting, Shen, Keng, Lang, Jing He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604507/
https://www.ncbi.nlm.nih.gov/pubmed/28923080
http://dx.doi.org/10.1186/s13048-017-0361-0
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author Zhao, Yu
Wang, Shu
Qu, Yi-Min
Ji, Yu-Ting
Shen, Keng
Lang, Jing He
author_facet Zhao, Yu
Wang, Shu
Qu, Yi-Min
Ji, Yu-Ting
Shen, Keng
Lang, Jing He
author_sort Zhao, Yu
collection PubMed
description BACKGROUND: This study aimed to identify the clinical and pathological characteristics and the possible prognostic factors for Chinese patients with early-stage ovarian endometrioid carcinoma. METHODS: The present study reviewed the medical records of patients who received initial treatment and a postoperative pathological diagnosis of ovarian endometrioid carcinoma at our center. In all, 78 patients had stage I ovarian endometrioid carcinoma. RESULTS: In this series, the 5-year overall survival rate and 5-year disease-free survival (DFS) rates of patients with stage I ovarian endometrioid carcinoma was 98.7% and 87.2%, respectively. Univariate analysis showed the factors that influence the DFS rates include menopausal status, FIGO stage, histological grade, lymphadenectomy, cytology of ascites. Multivariate analysis showed that grade 3 and lymphadenectomy were the independent prognostic factors of DFS for Stage I ovarian endometrioid carcinoma (P = 0.0259, 0.0276 respectively). However, the coexisting endometriosis, concomitant endometrial disorders, dissection of para-aortic lymph node and more courses of thermotherapy had no influence on DFS. Besides, it was found that 19.3% of patients in this series had synchronous early stage and well-to-moderate differentiated endometrial carcinoma. CONCLUSIONS: Grade 3 and lymphadenectomy were indicated as the independent factors of DFS for stage I patients with ovarian endometrioid carcinoma. The endometrial changes should be considered seriously when fertility-sparing surgery was planned.
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spelling pubmed-56045072017-09-20 Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma Zhao, Yu Wang, Shu Qu, Yi-Min Ji, Yu-Ting Shen, Keng Lang, Jing He J Ovarian Res Research BACKGROUND: This study aimed to identify the clinical and pathological characteristics and the possible prognostic factors for Chinese patients with early-stage ovarian endometrioid carcinoma. METHODS: The present study reviewed the medical records of patients who received initial treatment and a postoperative pathological diagnosis of ovarian endometrioid carcinoma at our center. In all, 78 patients had stage I ovarian endometrioid carcinoma. RESULTS: In this series, the 5-year overall survival rate and 5-year disease-free survival (DFS) rates of patients with stage I ovarian endometrioid carcinoma was 98.7% and 87.2%, respectively. Univariate analysis showed the factors that influence the DFS rates include menopausal status, FIGO stage, histological grade, lymphadenectomy, cytology of ascites. Multivariate analysis showed that grade 3 and lymphadenectomy were the independent prognostic factors of DFS for Stage I ovarian endometrioid carcinoma (P = 0.0259, 0.0276 respectively). However, the coexisting endometriosis, concomitant endometrial disorders, dissection of para-aortic lymph node and more courses of thermotherapy had no influence on DFS. Besides, it was found that 19.3% of patients in this series had synchronous early stage and well-to-moderate differentiated endometrial carcinoma. CONCLUSIONS: Grade 3 and lymphadenectomy were indicated as the independent factors of DFS for stage I patients with ovarian endometrioid carcinoma. The endometrial changes should be considered seriously when fertility-sparing surgery was planned. BioMed Central 2017-09-18 /pmc/articles/PMC5604507/ /pubmed/28923080 http://dx.doi.org/10.1186/s13048-017-0361-0 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Zhao, Yu
Wang, Shu
Qu, Yi-Min
Ji, Yu-Ting
Shen, Keng
Lang, Jing He
Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma
title Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma
title_full Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma
title_fullStr Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma
title_full_unstemmed Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma
title_short Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma
title_sort prognostic analysis for chinese patients with stage i ovarian endometrioid carcinoma
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604507/
https://www.ncbi.nlm.nih.gov/pubmed/28923080
http://dx.doi.org/10.1186/s13048-017-0361-0
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