Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer

BACKGROUND: Recent observations revealed Foxp3 participated in the development of cervical cancer. Furthermore, Foxp3 has a vital function in the lymphatic metastasis of cervical cancer. However, it is unclear whether Foxp3 is correlated with lymphangiogenesis of cervical cancer. METHODS: In this ex...

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Detalles Bibliográficos
Autores principales: Tang, Jiabu, Yang, Zheng, Wang, Zhuo, Li, Zhen, Li, Hongmei, Yin, Jinbao, Deng, Min, Zhu, Wei, Zeng, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604510/
https://www.ncbi.nlm.nih.gov/pubmed/28923073
http://dx.doi.org/10.1186/s12957-017-1221-5
Descripción
Sumario:BACKGROUND: Recent observations revealed Foxp3 participated in the development of cervical cancer. Furthermore, Foxp3 has a vital function in the lymphatic metastasis of cervical cancer. However, it is unclear whether Foxp3 is correlated with lymphangiogenesis of cervical cancer. METHODS: In this experiment, expression of Foxp3 and VEGF-C was detected in 50 cervical cancer samples by immunohistochemistry. In addition, we evaluated the association between Foxp3 and VEGF-C expression and lymphangiogenesis of cervical cancer evaluated by lymphatic vessel density. RESULTS: These data demonstrate Foxp3 is positively correlated with VEGF-C expression. Furthermore, Foxp3 is associated with lymphangiogenesis of cervical cancer. CONCLUSIONS: These results revealed Foxp3 play an important role in lymphangiogenesis of cervical cancer. TRIAL REGISTRATION: Gunagdong Medical University, PJ2013049

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