Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer

BACKGROUND: Recent observations revealed Foxp3 participated in the development of cervical cancer. Furthermore, Foxp3 has a vital function in the lymphatic metastasis of cervical cancer. However, it is unclear whether Foxp3 is correlated with lymphangiogenesis of cervical cancer. METHODS: In this ex...

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Autores principales: Tang, Jiabu, Yang, Zheng, Wang, Zhuo, Li, Zhen, Li, Hongmei, Yin, Jinbao, Deng, Min, Zhu, Wei, Zeng, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604510/
https://www.ncbi.nlm.nih.gov/pubmed/28923073
http://dx.doi.org/10.1186/s12957-017-1221-5
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author Tang, Jiabu
Yang, Zheng
Wang, Zhuo
Li, Zhen
Li, Hongmei
Yin, Jinbao
Deng, Min
Zhu, Wei
Zeng, Chao
author_facet Tang, Jiabu
Yang, Zheng
Wang, Zhuo
Li, Zhen
Li, Hongmei
Yin, Jinbao
Deng, Min
Zhu, Wei
Zeng, Chao
author_sort Tang, Jiabu
collection PubMed
description BACKGROUND: Recent observations revealed Foxp3 participated in the development of cervical cancer. Furthermore, Foxp3 has a vital function in the lymphatic metastasis of cervical cancer. However, it is unclear whether Foxp3 is correlated with lymphangiogenesis of cervical cancer. METHODS: In this experiment, expression of Foxp3 and VEGF-C was detected in 50 cervical cancer samples by immunohistochemistry. In addition, we evaluated the association between Foxp3 and VEGF-C expression and lymphangiogenesis of cervical cancer evaluated by lymphatic vessel density. RESULTS: These data demonstrate Foxp3 is positively correlated with VEGF-C expression. Furthermore, Foxp3 is associated with lymphangiogenesis of cervical cancer. CONCLUSIONS: These results revealed Foxp3 play an important role in lymphangiogenesis of cervical cancer. TRIAL REGISTRATION: Gunagdong Medical University, PJ2013049
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spelling pubmed-56045102017-09-20 Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer Tang, Jiabu Yang, Zheng Wang, Zhuo Li, Zhen Li, Hongmei Yin, Jinbao Deng, Min Zhu, Wei Zeng, Chao World J Surg Oncol Research BACKGROUND: Recent observations revealed Foxp3 participated in the development of cervical cancer. Furthermore, Foxp3 has a vital function in the lymphatic metastasis of cervical cancer. However, it is unclear whether Foxp3 is correlated with lymphangiogenesis of cervical cancer. METHODS: In this experiment, expression of Foxp3 and VEGF-C was detected in 50 cervical cancer samples by immunohistochemistry. In addition, we evaluated the association between Foxp3 and VEGF-C expression and lymphangiogenesis of cervical cancer evaluated by lymphatic vessel density. RESULTS: These data demonstrate Foxp3 is positively correlated with VEGF-C expression. Furthermore, Foxp3 is associated with lymphangiogenesis of cervical cancer. CONCLUSIONS: These results revealed Foxp3 play an important role in lymphangiogenesis of cervical cancer. TRIAL REGISTRATION: Gunagdong Medical University, PJ2013049 BioMed Central 2017-09-18 /pmc/articles/PMC5604510/ /pubmed/28923073 http://dx.doi.org/10.1186/s12957-017-1221-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Tang, Jiabu
Yang, Zheng
Wang, Zhuo
Li, Zhen
Li, Hongmei
Yin, Jinbao
Deng, Min
Zhu, Wei
Zeng, Chao
Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer
title Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer
title_full Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer
title_fullStr Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer
title_full_unstemmed Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer
title_short Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer
title_sort foxp3 is correlated with vegf-c expression and lymphangiogenesis in cervical cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604510/
https://www.ncbi.nlm.nih.gov/pubmed/28923073
http://dx.doi.org/10.1186/s12957-017-1221-5
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