Variability of the drug response to nonsteroidal anti-inflammatory drugs according to cyclooxygenase-2 genetic polymorphism

PURPOSE: Cyclooxygenase (COX) is the main pharmacodynamic target of nonsteroidal anti-inflammatory drugs (NSAIDs). We investigated the inhibitory effects on COX-2 after NSAIDs administration using a lipopolysaccharide (LPS)-derived COX-2 induction model in whole blood, according to the genotypes of...

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Detalles Bibliográficos
Autores principales: Lee, Sook Joung, Park, Min Kyu, Shin, Dong-Seong, Chun, Min Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604555/
https://www.ncbi.nlm.nih.gov/pubmed/29066864
http://dx.doi.org/10.2147/DDDT.S143807

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