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Bone mineral density in patients with psoriatic arthritis: data from the Nord-Trøndelag Health Study 3

BACKGROUND: The risk of osteoporosis in patients with psoriatic arthritis (PsA) remains unclear. The aim of this study was to compare bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) in patients with PsA and controls. PATIENTS AND METHODS: Patients with PsA and controls...

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Detalles Bibliográficos
Autores principales: Gulati, Agnete Malm, Hoff, Mari, Salvesen, Øyvind, Dhainaut, Alvilde, Semb, Anne Grete, Kavanaugh, Arthur, Haugeberg, Glenn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RMD Open 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604602/
https://www.ncbi.nlm.nih.gov/pubmed/28955483
http://dx.doi.org/10.1136/rmdopen-2016-000413
Descripción
Sumario:BACKGROUND: The risk of osteoporosis in patients with psoriatic arthritis (PsA) remains unclear. The aim of this study was to compare bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) in patients with PsA and controls. PATIENTS AND METHODS: Patients with PsA and controls were recruited from the Nord-Trøndelag Health Study (HUNT) 3. RESULTS: Patients with PsA (n=69) and controls (n=11 703) were comparable in terms of age (56.8 vs 55.3 years, p=0.32), gender distribution (females 65.2% vs 64.3%, p=0.87) and postmenopausal status (75.6% vs 62.8%, p=0.08). Body mass index (BMI) was higher in patients with PsA compared with controls (28.5 vs 27.2 kg/m(2), p=0.01). After adjusting for potential confounding factors (including BMI), BMD was higher in patients with PsA compared with controls at lumbar spine 1–4 (1.213 vs 1.147 g/cm(2), p=0.003) and femoral neck (0.960 vs 0.926 g/cm(2), p=0.02), but not at total hip (1.013 vs 0.982 g/cm(2), p=0.11). Controls had significantly higher odds of having osteopenia or osteoporosis based on measurements of BMD in both the femoral neck (p=0.001), total hip (p=0.033) and lumbar spine (p=0.033). CONCLUSION: Our population-based data showed comparable BMD in patients with PsA and controls. This supports that the PsA population is not at increased risk of osteoporosis.