Cargando…
Bone mineral density in patients with psoriatic arthritis: data from the Nord-Trøndelag Health Study 3
BACKGROUND: The risk of osteoporosis in patients with psoriatic arthritis (PsA) remains unclear. The aim of this study was to compare bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) in patients with PsA and controls. PATIENTS AND METHODS: Patients with PsA and controls...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
RMD Open
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604602/ https://www.ncbi.nlm.nih.gov/pubmed/28955483 http://dx.doi.org/10.1136/rmdopen-2016-000413 |
_version_ | 1783264886187360256 |
---|---|
author | Gulati, Agnete Malm Hoff, Mari Salvesen, Øyvind Dhainaut, Alvilde Semb, Anne Grete Kavanaugh, Arthur Haugeberg, Glenn |
author_facet | Gulati, Agnete Malm Hoff, Mari Salvesen, Øyvind Dhainaut, Alvilde Semb, Anne Grete Kavanaugh, Arthur Haugeberg, Glenn |
author_sort | Gulati, Agnete Malm |
collection | PubMed |
description | BACKGROUND: The risk of osteoporosis in patients with psoriatic arthritis (PsA) remains unclear. The aim of this study was to compare bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) in patients with PsA and controls. PATIENTS AND METHODS: Patients with PsA and controls were recruited from the Nord-Trøndelag Health Study (HUNT) 3. RESULTS: Patients with PsA (n=69) and controls (n=11 703) were comparable in terms of age (56.8 vs 55.3 years, p=0.32), gender distribution (females 65.2% vs 64.3%, p=0.87) and postmenopausal status (75.6% vs 62.8%, p=0.08). Body mass index (BMI) was higher in patients with PsA compared with controls (28.5 vs 27.2 kg/m(2), p=0.01). After adjusting for potential confounding factors (including BMI), BMD was higher in patients with PsA compared with controls at lumbar spine 1–4 (1.213 vs 1.147 g/cm(2), p=0.003) and femoral neck (0.960 vs 0.926 g/cm(2), p=0.02), but not at total hip (1.013 vs 0.982 g/cm(2), p=0.11). Controls had significantly higher odds of having osteopenia or osteoporosis based on measurements of BMD in both the femoral neck (p=0.001), total hip (p=0.033) and lumbar spine (p=0.033). CONCLUSION: Our population-based data showed comparable BMD in patients with PsA and controls. This supports that the PsA population is not at increased risk of osteoporosis. |
format | Online Article Text |
id | pubmed-5604602 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | RMD Open |
record_format | MEDLINE/PubMed |
spelling | pubmed-56046022017-09-27 Bone mineral density in patients with psoriatic arthritis: data from the Nord-Trøndelag Health Study 3 Gulati, Agnete Malm Hoff, Mari Salvesen, Øyvind Dhainaut, Alvilde Semb, Anne Grete Kavanaugh, Arthur Haugeberg, Glenn RMD Open Psoriatic Arthritis BACKGROUND: The risk of osteoporosis in patients with psoriatic arthritis (PsA) remains unclear. The aim of this study was to compare bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) in patients with PsA and controls. PATIENTS AND METHODS: Patients with PsA and controls were recruited from the Nord-Trøndelag Health Study (HUNT) 3. RESULTS: Patients with PsA (n=69) and controls (n=11 703) were comparable in terms of age (56.8 vs 55.3 years, p=0.32), gender distribution (females 65.2% vs 64.3%, p=0.87) and postmenopausal status (75.6% vs 62.8%, p=0.08). Body mass index (BMI) was higher in patients with PsA compared with controls (28.5 vs 27.2 kg/m(2), p=0.01). After adjusting for potential confounding factors (including BMI), BMD was higher in patients with PsA compared with controls at lumbar spine 1–4 (1.213 vs 1.147 g/cm(2), p=0.003) and femoral neck (0.960 vs 0.926 g/cm(2), p=0.02), but not at total hip (1.013 vs 0.982 g/cm(2), p=0.11). Controls had significantly higher odds of having osteopenia or osteoporosis based on measurements of BMD in both the femoral neck (p=0.001), total hip (p=0.033) and lumbar spine (p=0.033). CONCLUSION: Our population-based data showed comparable BMD in patients with PsA and controls. This supports that the PsA population is not at increased risk of osteoporosis. RMD Open 2017-07-13 /pmc/articles/PMC5604602/ /pubmed/28955483 http://dx.doi.org/10.1136/rmdopen-2016-000413 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Psoriatic Arthritis Gulati, Agnete Malm Hoff, Mari Salvesen, Øyvind Dhainaut, Alvilde Semb, Anne Grete Kavanaugh, Arthur Haugeberg, Glenn Bone mineral density in patients with psoriatic arthritis: data from the Nord-Trøndelag Health Study 3 |
title | Bone mineral density in patients with psoriatic arthritis: data from the Nord-Trøndelag Health Study 3 |
title_full | Bone mineral density in patients with psoriatic arthritis: data from the Nord-Trøndelag Health Study 3 |
title_fullStr | Bone mineral density in patients with psoriatic arthritis: data from the Nord-Trøndelag Health Study 3 |
title_full_unstemmed | Bone mineral density in patients with psoriatic arthritis: data from the Nord-Trøndelag Health Study 3 |
title_short | Bone mineral density in patients with psoriatic arthritis: data from the Nord-Trøndelag Health Study 3 |
title_sort | bone mineral density in patients with psoriatic arthritis: data from the nord-trøndelag health study 3 |
topic | Psoriatic Arthritis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604602/ https://www.ncbi.nlm.nih.gov/pubmed/28955483 http://dx.doi.org/10.1136/rmdopen-2016-000413 |
work_keys_str_mv | AT gulatiagnetemalm bonemineraldensityinpatientswithpsoriaticarthritisdatafromthenordtrøndelaghealthstudy3 AT hoffmari bonemineraldensityinpatientswithpsoriaticarthritisdatafromthenordtrøndelaghealthstudy3 AT salvesenøyvind bonemineraldensityinpatientswithpsoriaticarthritisdatafromthenordtrøndelaghealthstudy3 AT dhainautalvilde bonemineraldensityinpatientswithpsoriaticarthritisdatafromthenordtrøndelaghealthstudy3 AT sembannegrete bonemineraldensityinpatientswithpsoriaticarthritisdatafromthenordtrøndelaghealthstudy3 AT kavanaugharthur bonemineraldensityinpatientswithpsoriaticarthritisdatafromthenordtrøndelaghealthstudy3 AT haugebergglenn bonemineraldensityinpatientswithpsoriaticarthritisdatafromthenordtrøndelaghealthstudy3 |