Nardilysin is involved in autoimmune arthritis via the regulation of tumour necrosis factor alpha secretion

OBJECTIVE: Tumour necrosis factor alpha (TNF-α) plays an important role in rheumatoid arthritis (RA). TNF-α is synthesised as a membrane-anchored precursor and is fully activated by a disintegrin and metalloproteinase 17 (ADAM17)-mediated ectodomain shedding. Nardilysin (NRDC) facilitates ectodomain...

Descripción completa

Detalles Bibliográficos
Autores principales: Fujii, Takayuki, Nishi, Eiichiro, Ito, Hiromu, Yoshitomi, Hiroyuki, Furu, Moritoshi, Okabe, Namiko, Ohno, Mikiko, Nishi, Kiyoto, Morita, Yusuke, Morita, Yugo, Azukizawa, Masayuki, Okahata, Akinori, Tomizawa, Takuya, Kimura, Takeshi, Matsuda, Shuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RMD Open 2017
Materias:
Animal Models
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604610/
https://www.ncbi.nlm.nih.gov/pubmed/28955486
http://dx.doi.org/10.1136/rmdopen-2017-000436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604610/
https://www.ncbi.nlm.nih.gov/pubmed/28955486
http://dx.doi.org/10.1136/rmdopen-2017-000436

Ejemplares similares