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Prognostic impact of surgical margin in patients with hepatocellular carcinoma: A meta-analysis

BACKGROUND: Surgical margin is an important prognostic factor in hepatectomy for patients with hepatocellular carcinoma (HCC). But the extent of surgical margins is still controversial. Our study was designed to systematically evaluate the prognosis of different width of resection margin. METHODS: W...

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Autores principales: Zhong, Fu-Ping, Zhang, Yu-Jun, Liu, Ying, Zou, Shu-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604664/
https://www.ncbi.nlm.nih.gov/pubmed/28906395
http://dx.doi.org/10.1097/MD.0000000000008043
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author Zhong, Fu-Ping
Zhang, Yu-Jun
Liu, Ying
Zou, Shu-Bing
author_facet Zhong, Fu-Ping
Zhang, Yu-Jun
Liu, Ying
Zou, Shu-Bing
author_sort Zhong, Fu-Ping
collection PubMed
description BACKGROUND: Surgical margin is an important prognostic factor in hepatectomy for patients with hepatocellular carcinoma (HCC). But the extent of surgical margins is still controversial. Our study was designed to systematically evaluate the prognosis of different width of resection margin. METHODS: We conducted comprehensive searches of electronic databases including PubMed, MEDLINE, EMBASE, Cochrane, and the ISI Web of Science for relevant studies. A meta-analysis was performed by RevMan 5.3 software. RESULTS: A total of 7 studies comprising 1932 patients were included. The patients with wider surgical margin were significantly higher than those with narrow surgical margin on 3-year overall survival (odds ratio [OR]: 1.58, 95% confidence interval (95% CI): 1.21–2.06, P = .0008), 5-year overall survival (OR: 1.76, 95% CI: 1.20–2.59, P = .004), 1-year disease-free survival (DFS)/recurrence-free survival (RFS) (OR: 1.43, 95% CI: 1.12–1.82, P = .005), 3-year DFS/RFS (OR: 1.66, 95% CI: 1.35–2.03, P < .00001), and 5-year DFS/RFS (OR: 1.69, 95% CI: 1.37–2.08, P < .00001). There was no significant difference in the 1-year overall survival rate for the 2 groups (OR: 1.24, 95% CI: 0.89–1.72, P = .20). CONCLUSION: In comparison with the narrow surgical margin group (<1 cm), the wide surgical margin (≥1 cm) can significantly improve the prognosis in patients with HCC.
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spelling pubmed-56046642017-10-03 Prognostic impact of surgical margin in patients with hepatocellular carcinoma: A meta-analysis Zhong, Fu-Ping Zhang, Yu-Jun Liu, Ying Zou, Shu-Bing Medicine (Baltimore) 7100 BACKGROUND: Surgical margin is an important prognostic factor in hepatectomy for patients with hepatocellular carcinoma (HCC). But the extent of surgical margins is still controversial. Our study was designed to systematically evaluate the prognosis of different width of resection margin. METHODS: We conducted comprehensive searches of electronic databases including PubMed, MEDLINE, EMBASE, Cochrane, and the ISI Web of Science for relevant studies. A meta-analysis was performed by RevMan 5.3 software. RESULTS: A total of 7 studies comprising 1932 patients were included. The patients with wider surgical margin were significantly higher than those with narrow surgical margin on 3-year overall survival (odds ratio [OR]: 1.58, 95% confidence interval (95% CI): 1.21–2.06, P = .0008), 5-year overall survival (OR: 1.76, 95% CI: 1.20–2.59, P = .004), 1-year disease-free survival (DFS)/recurrence-free survival (RFS) (OR: 1.43, 95% CI: 1.12–1.82, P = .005), 3-year DFS/RFS (OR: 1.66, 95% CI: 1.35–2.03, P < .00001), and 5-year DFS/RFS (OR: 1.69, 95% CI: 1.37–2.08, P < .00001). There was no significant difference in the 1-year overall survival rate for the 2 groups (OR: 1.24, 95% CI: 0.89–1.72, P = .20). CONCLUSION: In comparison with the narrow surgical margin group (<1 cm), the wide surgical margin (≥1 cm) can significantly improve the prognosis in patients with HCC. Wolters Kluwer Health 2017-09-15 /pmc/articles/PMC5604664/ /pubmed/28906395 http://dx.doi.org/10.1097/MD.0000000000008043 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 7100
Zhong, Fu-Ping
Zhang, Yu-Jun
Liu, Ying
Zou, Shu-Bing
Prognostic impact of surgical margin in patients with hepatocellular carcinoma: A meta-analysis
title Prognostic impact of surgical margin in patients with hepatocellular carcinoma: A meta-analysis
title_full Prognostic impact of surgical margin in patients with hepatocellular carcinoma: A meta-analysis
title_fullStr Prognostic impact of surgical margin in patients with hepatocellular carcinoma: A meta-analysis
title_full_unstemmed Prognostic impact of surgical margin in patients with hepatocellular carcinoma: A meta-analysis
title_short Prognostic impact of surgical margin in patients with hepatocellular carcinoma: A meta-analysis
title_sort prognostic impact of surgical margin in patients with hepatocellular carcinoma: a meta-analysis
topic 7100
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604664/
https://www.ncbi.nlm.nih.gov/pubmed/28906395
http://dx.doi.org/10.1097/MD.0000000000008043
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