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Unexpected genomic features in widespread intracellular bacteria: evidence for motility of marine chlamydiae
Chlamydiae are obligate intracellular bacteria comprising important human pathogens and symbionts of protists. Molecular evidence indicates a tremendous diversity of chlamydiae particularly in marine environments, yet our current knowledge is based mainly on terrestrial representatives. Here we prov...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604735/ https://www.ncbi.nlm.nih.gov/pubmed/28644443 http://dx.doi.org/10.1038/ismej.2017.95 |
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author | Collingro, Astrid Köstlbacher, Stephan Mussmann, Marc Stepanauskas, Ramunas Hallam, Steven J Horn, Matthias |
author_facet | Collingro, Astrid Köstlbacher, Stephan Mussmann, Marc Stepanauskas, Ramunas Hallam, Steven J Horn, Matthias |
author_sort | Collingro, Astrid |
collection | PubMed |
description | Chlamydiae are obligate intracellular bacteria comprising important human pathogens and symbionts of protists. Molecular evidence indicates a tremendous diversity of chlamydiae particularly in marine environments, yet our current knowledge is based mainly on terrestrial representatives. Here we provide first insights into the biology of marine chlamydiae representing three divergent clades. Our analysis of single-cell amplified genomes revealed hallmarks of the chlamydial lifestyle, supporting the ancient origin of their characteristic developmental cycle and major virulence mechanisms. Surprisingly, these chlamydial genomes encode a complete flagellar apparatus, a previously unreported feature. We show that flagella are an ancient trait that was subject to differential gene loss among extant chlamydiae. Together with a chemotaxis system, these marine chlamydiae are likely motile, with flagella potentially playing a role during host cell infection. This study broadens our view on chlamydial biology and indicates a largely underestimated potential to adapt to different hosts and environments. |
format | Online Article Text |
id | pubmed-5604735 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-56047352017-10-01 Unexpected genomic features in widespread intracellular bacteria: evidence for motility of marine chlamydiae Collingro, Astrid Köstlbacher, Stephan Mussmann, Marc Stepanauskas, Ramunas Hallam, Steven J Horn, Matthias ISME J Original Article Chlamydiae are obligate intracellular bacteria comprising important human pathogens and symbionts of protists. Molecular evidence indicates a tremendous diversity of chlamydiae particularly in marine environments, yet our current knowledge is based mainly on terrestrial representatives. Here we provide first insights into the biology of marine chlamydiae representing three divergent clades. Our analysis of single-cell amplified genomes revealed hallmarks of the chlamydial lifestyle, supporting the ancient origin of their characteristic developmental cycle and major virulence mechanisms. Surprisingly, these chlamydial genomes encode a complete flagellar apparatus, a previously unreported feature. We show that flagella are an ancient trait that was subject to differential gene loss among extant chlamydiae. Together with a chemotaxis system, these marine chlamydiae are likely motile, with flagella potentially playing a role during host cell infection. This study broadens our view on chlamydial biology and indicates a largely underestimated potential to adapt to different hosts and environments. Nature Publishing Group 2017-10 2017-06-23 /pmc/articles/PMC5604735/ /pubmed/28644443 http://dx.doi.org/10.1038/ismej.2017.95 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Original Article Collingro, Astrid Köstlbacher, Stephan Mussmann, Marc Stepanauskas, Ramunas Hallam, Steven J Horn, Matthias Unexpected genomic features in widespread intracellular bacteria: evidence for motility of marine chlamydiae |
title | Unexpected genomic features in widespread intracellular bacteria: evidence for motility of marine chlamydiae |
title_full | Unexpected genomic features in widespread intracellular bacteria: evidence for motility of marine chlamydiae |
title_fullStr | Unexpected genomic features in widespread intracellular bacteria: evidence for motility of marine chlamydiae |
title_full_unstemmed | Unexpected genomic features in widespread intracellular bacteria: evidence for motility of marine chlamydiae |
title_short | Unexpected genomic features in widespread intracellular bacteria: evidence for motility of marine chlamydiae |
title_sort | unexpected genomic features in widespread intracellular bacteria: evidence for motility of marine chlamydiae |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604735/ https://www.ncbi.nlm.nih.gov/pubmed/28644443 http://dx.doi.org/10.1038/ismej.2017.95 |
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